Assay Detail
Binding
CHEMBL2389179
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-citalopram from Sprague-Dawley rat brain SERT after 1 hr
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Discovery of a potent, dual serotonin and norepinephrine reuptake inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.77 | 10.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1175 | DULOXETINE | 4.0 | 1 | 10.09 |
| CHEMBL2386162 | — | — | 1 | 9.80 |
| CHEMBL637 | VENLAFAXINE | 4.0 | 1 | 7.60 |
| CHEMBL259209 | MILNACIPRAN | 4.0 | 1 | 7.57 |
| CHEMBL1118 | DESVENLAFAXINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1175 | DULOXETINE | Ki | = | 0.082 | nM | 10.09 |
| CHEMBL2386162 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL637 | VENLAFAXINE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL259209 | MILNACIPRAN | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL1118 | DESVENLAFAXINE | Ki | > | 324.0 | nM | - |