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Assay Detail

CHEMBL2390496

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Rattus norvegicus
Cell Type L6
Confidence 1 — Organism
Curated By Autocuration

Target

L6 (CHEMBL614793)
Type CELL-LINE
Organism Rattus norvegicus

Publication

New Promising Compounds with in Vitro Nanomolar Activity against Trypanosoma cruzi.
Friggeri L, Scipione L, Costi R, Kaiser M, Moraca F, Zamperini C, Botta B, Di Santo R, De Vita D, Brun R, Tortorella S.
ACS Med Chem Lett (2013) 4 : 538 -541
PubMed 24900706 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.03 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL61 PODOFILOX 4.0 1 9.00
CHEMBL1946928 1 4.89
CHEMBL2385091 1 4.87
CHEMBL2386136 1 4.86
CHEMBL2386137 1 4.81
CHEMBL1946927 1 4.78
CHEMBL2386135 1 4.74
CHEMBL1946738 1 4.63
CHEMBL1946929 1 4.57
CHEMBL2386134 1 4.56
CHEMBL2386138 1 4.50
CHEMBL2386132 1 4.10
CHEMBL2386133 1 -
CHEMBL2386131 1 -
CHEMBL1946741 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL61 PODOFILOX IC50 = 1.0 nM 9.00
CHEMBL1946928 IC50 = 12970.0 nM 4.89
CHEMBL2385091 IC50 = 13440.0 nM 4.87
CHEMBL2386136 IC50 = 13960.0 nM 4.86
CHEMBL2386137 IC50 = 15380.0 nM 4.81
CHEMBL1946927 IC50 = 16800.0 nM 4.78
CHEMBL2386135 IC50 = 18240.0 nM 4.74
CHEMBL1946738 IC50 = 23590.0 nM 4.63
CHEMBL1946929 IC50 = 27200.0 nM 4.57
CHEMBL2386134 IC50 = 27500.0 nM 4.56
CHEMBL2386138 IC50 = 31560.0 nM 4.50
CHEMBL2386132 IC50 = 79300.0 nM 4.10
CHEMBL2386133 IC50 = 237600.0 nM -
CHEMBL2386131 IC50 = 222100.0 nM -
CHEMBL1946741 IC50 = 182500.0 nM -