Compound Detail
CHEMBL2386137
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Basic Information
| ChEMBL ID | CHEMBL2386137 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JXJPHZOUDWRHCV-AWEZNQCLSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
411.7
MW (Da)
5.23
ALogP
5
HBA
1
HBD
69.0
PSA (Ų)
0.58
QED
1
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.01
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Trypanosoma cruzi CHEMBL368 | IC50 | 7.01 | 7.01 | 97.2 | 1 |
| L6 CHEMBL614793 | IC50 | 4.81 | 4.81 | 15380.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Trypanosoma cruzi | IC50 | = | 97.2 | nM | 7.01 | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen C2C4 amastigotes in... | 24900706 |
| L6 | IC50 | = | 15380.0 | nM | 4.81 | Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay | 24900706 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24900706 | 10.1021/ml400039r | Unchecked | 1 |
| 24900706 | 10.1021/ml400039r | L6 | 1 |
| 24900706 | 10.1021/ml400039r | Trypanosoma cruzi | 1 |
Data from ChEMBL 36 via Core Engine