Assay Detail
Functional
CHEMBL2393795
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Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and anti-inflammatory evaluations of β-lapachone derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.18 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107251 | 1400W | — | 1 | 6.70 |
| CHEMBL15192 | LAPACHONE | 2.0 | 1 | 6.33 |
| CHEMBL2391136 | — | — | 1 | 6.20 |
| CHEMBL2391135 | — | — | 1 | 6.13 |
| CHEMBL349325 | — | — | 1 | 6.09 |
| CHEMBL2391134 | — | — | 1 | 6.07 |
| CHEMBL2391137 | — | — | 1 | 6.06 |
| CHEMBL2391138 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107251 | 1400W | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL15192 | LAPACHONE | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL2391136 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL2391135 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL349325 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL2391134 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL2391137 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL2391138 | — | IC50 | = | 1290.0 | nM | 5.89 |