Compound Detail
CHEMBL2391136
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Basic Information
| ChEMBL ID | CHEMBL2391136 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MOWNPTIFTNOHNB-VLGSPTGOSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
264.3
MW (Da)
2.90
ALogP
4
HBA
2
HBD
61.7
PSA (Ų)
0.65
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.2
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| RAW264.7 CHEMBL612557 | IC50 | 6.2 | 5.99 | 630.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| RAW264.7 | IC50 | = | 630.0 | nM | 6.2 | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-... | 23232148 |
| RAW264.7 | IC50 | = | 1670.0 | nM | 5.78 | Cytotoxicity against mouse RAW264.7 cells assessed as cell viability after 24 hr... | 23232148 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23232148 | 10.1016/j.bmc.2012.10.047 | RAW264.7 | 2 |
Data from ChEMBL 36 via Core Engine