Assay Detail

CHEMBL2394331

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Binding

Displacement of [3H]Paroxetine from human recombinant SERT expressed in HEK293 cells after 60 mins

ChEMBL ↗

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Target

Sodium-dependent serotonin transporter (CHEMBL228) ↗

Open DB target context

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Sodium-dependent serotonin transporter (CHEMBL228) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Sodium-dependent serotonin transporter

CHEMBL228

Anchored from Assay target.

Protein identity Sodium-dependent serotonin transporter

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Cell Type	HEK293
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Sodium-dependent serotonin transporter (CHEMBL228) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells.

Germain AR, Carmody LC, Nag PP, Morgan B, Verplank L, Fernandez C, Donckele E, Feng Y, Perez JR, Dandapani S, Palmer M, Lander ES, Gupta PB, Schreiber SL, Munoz B.
Bioorg Med Chem Lett (2013) 23 : 1834 -1838
PubMed 23403082 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	8.85	8.85
IC50	1	8.07	8.07

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL41	FLUOXETINE	4.0	2	8.85

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL41	FLUOXETINE	Ki	=	1.4	nM	8.85
CHEMBL41	FLUOXETINE	IC50	=	8.6	nM	8.07