Assay Detail
Binding
CHEMBL2394462
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Inhibition of SARS coronavirus 3C-like protease cis-cleavage activity transfected in african green monkey Vero cells using SAVLQSGFRK as substrate after 5 hrs by luciferase reporter gene assay
13
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome-related coronavirus |
| Cell Type | Vero |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Replicase polyprotein 1ab (CHEMBL5118) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome-related coronavirus |
Publication
Dieckol, a SARS-CoV 3CL(pro) inhibitor, isolated from the edible brown algae Ecklonia cava.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.17 | 4.17 |
| Inhibition | 6 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL508791 | DIECKOL | — | 2 | 4.17 |
| CHEMBL473159 | PHLOROGLUCINOL | 3.0 | 1 | - |
| CHEMBL510508 | PHLOROFUCOFUROECKOL A | — | 2 | - |
| CHEMBL459393 | FUCODIPHLOROETHOL G | — | 2 | - |
| CHEMBL456228 | — | — | 2 | - |
| CHEMBL2391423 | 2-PHLOROECKOL | — | 2 | - |
| CHEMBL559870 | DIOXINODEHYDROECKOL | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL508791 | DIECKOL | IC50 | = | 68100.0 | nM | 4.17 |
| CHEMBL473159 | PHLOROGLUCINOL | IC50 | - | — | - | |
| CHEMBL510508 | PHLOROFUCOFUROECKOL A | Inhibition | - | % | - | |
| CHEMBL508791 | DIECKOL | Inhibition | - | % | - | |
| CHEMBL459393 | FUCODIPHLOROETHOL G | Inhibition | - | % | - | |
| CHEMBL456228 | — | Inhibition | - | % | - | |
| CHEMBL2391423 | 2-PHLOROECKOL | Inhibition | - | % | - | |
| CHEMBL559870 | DIOXINODEHYDROECKOL | Inhibition | - | % | - | |
| CHEMBL459393 | FUCODIPHLOROETHOL G | IC50 | = | 177100.0 | nM | - |
| CHEMBL510508 | PHLOROFUCOFUROECKOL A | IC50 | = | 174600.0 | nM | - |
| CHEMBL559870 | DIOXINODEHYDROECKOL | IC50 | = | 146500.0 | nM | - |
| CHEMBL2391423 | 2-PHLOROECKOL | IC50 | = | 112200.0 | nM | - |
| CHEMBL456228 | — | IC50 | = | 112000.0 | nM | - |