Assay Detail
Binding
CHEMBL2395025
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Inhibition of equine serum BChE using butylthiocholine iodide as substrate preincubated for 10 mins prior to substrate addition by Ellman's method
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of 4-substituted coumarins as novel acetylcholinesterase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 4.36 | 5.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1678 | DONEPEZIL HYDROCHLORIDE | 4.0 | 1 | 5.27 |
| CHEMBL2393509 | — | — | 1 | 4.39 |
| CHEMBL2393508 | — | — | 1 | 4.35 |
| CHEMBL2393507 | — | — | 1 | 4.19 |
| CHEMBL2393500 | — | — | 1 | 4.12 |
| CHEMBL2390982 | — | — | 1 | 4.12 |
| CHEMBL2393498 | — | — | 1 | 4.05 |
| CHEMBL2390990 | — | — | 1 | - |
| CHEMBL2393513 | — | — | 1 | - |
| CHEMBL2393512 | — | — | 1 | - |
| CHEMBL2393511 | — | — | 1 | - |
| CHEMBL2393510 | — | — | 1 | - |
| CHEMBL2393505 | — | — | 1 | - |
| CHEMBL2393504 | — | — | 1 | - |
| CHEMBL2393503 | — | — | 1 | - |
| CHEMBL2393502 | — | — | 1 | - |
| CHEMBL2393501 | — | — | 1 | - |
| CHEMBL2393499 | — | — | 1 | - |
| CHEMBL2393497 | — | — | 1 | - |
| CHEMBL2393506 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1678 | DONEPEZIL HYDROCHLORIDE | IC50 | = | 5380.0 | nM | 5.27 |
| CHEMBL2393509 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL2393508 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL2393507 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL2393500 | — | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL2390982 | — | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL2393498 | — | IC50 | = | 89000.0 | nM | 4.05 |
| CHEMBL2390990 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2393513 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2393512 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2393511 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2393510 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2393505 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2393504 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2393503 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2393502 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2393501 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2393499 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2393497 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2393506 | — | IC50 | > | 100000.0 | nM | - |