Assay Detail
Binding
CHEMBL2395054
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Inhibition of recombinant SARS coronavirus 3C-like protease trans-cleavage activity by ELISA
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome-related coronavirus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Replicase polyprotein 1ab (CHEMBL5118) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome-related coronavirus |
Publication
Dieckol, a SARS-CoV 3CL(pro) inhibitor, isolated from the edible brown algae Ecklonia cava.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.22 | 4.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL399121 | HESPERETIN | 0.5 | 1 | 4.22 |
| CHEMBL40275 | ALOE-EMODIN | — | 1 | - |
| CHEMBL8145 | DAIDZEIN | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL399121 | HESPERETIN | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL40275 | ALOE-EMODIN | IC50 | = | 132000.0 | nM | - |
| CHEMBL8145 | DAIDZEIN | IC50 | = | 105000.0 | nM | - |