Assay Detail
Functional
CHEMBL2396491
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human A2780 cells after 72 hrs by sulforhodamine B assay
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 6.67 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2393190 | — | — | 1 | 7.82 |
| CHEMBL2393173 | — | — | 1 | 7.38 |
| CHEMBL2393171 | — | — | 1 | 7.28 |
| CHEMBL2393183 | — | — | 1 | 7.16 |
| CHEMBL2393163 | — | — | 1 | 7.12 |
| CHEMBL2393168 | — | — | 1 | 7.10 |
| CHEMBL2393166 | — | — | 1 | 7.00 |
| CHEMBL2393167 | — | — | 1 | 6.96 |
| CHEMBL2393164 | — | — | 1 | 6.87 |
| CHEMBL2391572 | — | — | 1 | 6.84 |
| CHEMBL2393176 | — | — | 1 | 6.84 |
| CHEMBL2393162 | — | — | 1 | 6.73 |
| CHEMBL2393158 | — | — | 1 | 6.60 |
| CHEMBL2393170 | — | — | 1 | 6.46 |
| CHEMBL2393172 | — | — | 1 | 6.43 |
| CHEMBL2393169 | — | — | 1 | 6.39 |
| CHEMBL2393165 | — | — | 1 | 6.23 |
| CHEMBL2393191 | — | — | 1 | 6.13 |
| CHEMBL2393185 | — | — | 1 | 6.13 |
| CHEMBL2393186 | — | — | 1 | 6.07 |
| CHEMBL2391567 | — | — | 1 | 6.00 |
| CHEMBL2393177 | — | — | 1 | 5.96 |
| CHEMBL2393159 | — | — | 1 | 5.80 |
| CHEMBL2393179 | — | — | 1 | - |
| CHEMBL2393192 | — | — | 1 | - |
| CHEMBL2393193 | — | — | 1 | - |
| CHEMBL2393174 | — | — | 1 | - |
| CHEMBL2393175 | — | — | 1 | - |
| CHEMBL2393160 | — | — | 1 | - |
| CHEMBL2393178 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2393190 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2393173 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL2393171 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL2393183 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL2393163 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL2393168 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL2393166 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL2393167 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL2393164 | — | IC50 | = | 136.0 | nM | 6.87 |
| CHEMBL2391572 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL2393176 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL2393162 | — | IC50 | = | 188.0 | nM | 6.73 |
| CHEMBL2393158 | — | IC50 | = | 251.0 | nM | 6.60 |
| CHEMBL2393170 | — | IC50 | = | 351.0 | nM | 6.46 |
| CHEMBL2393172 | — | IC50 | = | 369.0 | nM | 6.43 |
| CHEMBL2393169 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL2393165 | — | IC50 | = | 594.0 | nM | 6.23 |
| CHEMBL2393191 | — | IC50 | = | 745.0 | nM | 6.13 |
| CHEMBL2393185 | — | IC50 | = | 739.0 | nM | 6.13 |
| CHEMBL2393186 | — | IC50 | = | 846.0 | nM | 6.07 |
| CHEMBL2391567 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL2393177 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL2393159 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL2393187 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL2393189 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL2393184 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL2393161 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL2393182 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL2393181 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL2393180 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL2391551 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL2393188 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL2393178 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL2393160 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL2393175 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL2393174 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL2393193 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL2393192 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL2393179 | — | IC50 | > | 2000.0 | nM | - |