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Assay Detail

CHEMBL2400522

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human DU145 cells after 96 hrs by trypan blue exclusion assay
ChEMBL ↗
104
Total Activities
50
Compounds Tested
3
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type DU-145
Confidence 1 — Organism
Curated By Autocuration

Target

DU-145 (CHEMBL613508) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Design, synthesis, and biological evaluation of (E)-N-aryl-2-arylethenesulfonamide analogues as potent and orally bioavailable microtubule-targeted anticancer agents.
Reddy MV, Mallireddigari MR, Pallela VR, Cosenza SC, Billa VK, Akula B, Subbaiah DR, Bharathi EV, Padgaonkar A, Lv H, Gallo JM, Reddy EP.
J Med Chem (2013) 56 : 5562 -5586
PubMed 23750455 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Activity 50 - -
IC50 50 5.59 8.30
GI50 4 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2397992 — — 3 8.30
CHEMBL2397989 — — 2 8.05
CHEMBL2397988 — — 3 7.52
CHEMBL2397990 — — 2 7.40
CHEMBL2397979 — — 2 7.40
CHEMBL2397980 — — 3 7.16
CHEMBL2397961 — — 2 7.12
CHEMBL2397959 — — 2 7.12
CHEMBL2397960 — — 2 7.12
CHEMBL2397972 — — 2 7.00
CHEMBL2397973 — — 2 6.70
CHEMBL2397987 — — 2 6.70
CHEMBL2397982 — — 3 6.70
CHEMBL2397962 — — 2 6.60
CHEMBL2397971 — — 2 6.46
CHEMBL2397981 — — 2 6.43
CHEMBL2397978 — — 2 6.40
CHEMBL2397991 — — 2 5.60
CHEMBL2397963 — — 2 5.60
CHEMBL2397974 — — 2 5.60
CHEMBL2397975 — — 2 5.60
CHEMBL2398005 — — 2 5.30
CHEMBL2397964 — — 2 5.30
CHEMBL2398004 — — 2 5.30
CHEMBL2397976 — — 2 5.30
CHEMBL2396669 — — 2 5.12
CHEMBL2397977 — — 2 5.12
CHEMBL2398003 — — 2 5.00
CHEMBL2397984 — — 2 5.00
CHEMBL2397986 — — 2 5.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2397992 — IC50 = 5.0 nM 8.30
CHEMBL2397989 — IC50 = 9.0 nM 8.05
CHEMBL2397988 — IC50 = 30.0 nM 7.52
CHEMBL2397990 — IC50 = 40.0 nM 7.40
CHEMBL2397979 — IC50 = 40.0 nM 7.40
CHEMBL2397980 — IC50 = 70.0 nM 7.16
CHEMBL2397959 — IC50 = 75.0 nM 7.12
CHEMBL2397960 — IC50 = 75.0 nM 7.12
CHEMBL2397961 — IC50 = 75.0 nM 7.12
CHEMBL2397972 — IC50 = 100.0 nM 7.00
CHEMBL2397982 — IC50 = 200.0 nM 6.70
CHEMBL2397987 — IC50 = 200.0 nM 6.70
CHEMBL2397973 — IC50 = 200.0 nM 6.70
CHEMBL2397962 — IC50 = 250.0 nM 6.60
CHEMBL2397971 — IC50 = 350.0 nM 6.46
CHEMBL2397981 — IC50 = 375.0 nM 6.43
CHEMBL2397978 — IC50 = 400.0 nM 6.40
CHEMBL2397991 — IC50 = 2500.0 nM 5.60
CHEMBL2397963 — IC50 = 2500.0 nM 5.60
CHEMBL2397974 — IC50 = 2500.0 nM 5.60
CHEMBL2397975 — IC50 = 2500.0 nM 5.60
CHEMBL2397976 — IC50 = 5000.0 nM 5.30
CHEMBL2397964 — IC50 = 5000.0 nM 5.30
CHEMBL2398004 — IC50 = 5000.0 nM 5.30
CHEMBL2398005 — IC50 = 5000.0 nM 5.30
CHEMBL2396669 — IC50 = 7500.0 nM 5.12
CHEMBL2397977 — IC50 = 7500.0 nM 5.12
CHEMBL2398000 — IC50 = 10000.0 nM 5.00
CHEMBL2397965 — IC50 = 10000.0 nM 5.00
CHEMBL2397999 — IC50 = 10000.0 nM 5.00
CHEMBL2397997 — IC50 = 10000.0 nM 5.00
CHEMBL2397996 — IC50 = 10000.0 nM 5.00
CHEMBL2397984 — IC50 = 10000.0 nM 5.00
CHEMBL2398003 — IC50 = 10000.0 nM 5.00
CHEMBL2398002 — IC50 = 10000.0 nM 5.00
CHEMBL463270 — IC50 = 10000.0 nM 5.00
CHEMBL2397986 — IC50 = 10000.0 nM 5.00
CHEMBL2398006 — IC50 = 15000.0 nM 4.82
CHEMBL2398001 — IC50 = 20000.0 nM 4.70
CHEMBL2397994 — IC50 = 35000.0 nM 4.46
CHEMBL2397970 — IC50 = 35000.0 nM 4.46
CHEMBL2397969 — IC50 = 35000.0 nM 4.46
CHEMBL2397983 — IC50 = 35000.0 nM 4.46
CHEMBL2397985 — IC50 = 75000.0 nM 4.12
CHEMBL2397993 — IC50 = 75000.0 nM 4.12
CHEMBL2397967 — IC50 = 75000.0 nM 4.12
CHEMBL2397968 — IC50 = 100000.0 nM 4.00
CHEMBL2397966 — IC50 = 100000.0 nM 4.00
CHEMBL2397995 — IC50 = 100000.0 nM 4.00
CHEMBL2397998 — IC50 = 100000.0 nM 4.00