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Assay Detail

CHEMBL2400701

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antineuroinflammatory activity in mouse BV2 cells assessed as reduction of LPS-induced nitric oxide production treated 3 hrs before LPS addition measured after 24 hrs by Griess assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type BV-2
Confidence 1 — Organism
Curated By Autocuration

Target

BV-2 (CHEMBL614781)
Type CELL-LINE
Organism Mus musculus

Publication

Synthesis and neuroprotective effect of E-3,4-dihydroxy styryl aralkyl ketones derivatives against oxidative stress and inflammation.
Ning X, Guo Y, Ma X, Zhu R, Tian C, Wang X, Ma Z, Zhang Z, Liu J.
Bioorg Med Chem Lett (2013) 23 : 3700 -3703
PubMed 23726032 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 5.09 5.38

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2397184 1 5.38
CHEMBL2397183 1 5.28
CHEMBL2397182 1 5.26
CHEMBL2397177 1 5.23
CHEMBL2397185 1 5.21
CHEMBL2397175 1 5.20
CHEMBL319244 CAFFEIC ACID PHENETHYL ESTER 1 5.19
CHEMBL2397176 1 5.19
CHEMBL2397179 1 5.08
CHEMBL2397181 1 5.03
CHEMBL2397172 1 4.99
CHEMBL2397174 1 4.97
CHEMBL2397178 1 4.91
CHEMBL2397180 1 4.90
CHEMBL127028 1 4.85
CHEMBL2397173 1 4.84

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2397184 IC50 = 4200.0 nM 5.38
CHEMBL2397183 IC50 = 5300.0 nM 5.28
CHEMBL2397182 IC50 = 5500.0 nM 5.26
CHEMBL2397177 IC50 = 5900.0 nM 5.23
CHEMBL2397185 IC50 = 6200.0 nM 5.21
CHEMBL2397175 IC50 = 6300.0 nM 5.20
CHEMBL319244 CAFFEIC ACID PHENETHYL ESTER IC50 = 6400.0 nM 5.19
CHEMBL2397176 IC50 = 6400.0 nM 5.19
CHEMBL2397179 IC50 = 8300.0 nM 5.08
CHEMBL2397181 IC50 = 9300.0 nM 5.03
CHEMBL2397172 IC50 = 10300.0 nM 4.99
CHEMBL2397174 IC50 = 10600.0 nM 4.97
CHEMBL2397178 IC50 = 12300.0 nM 4.91
CHEMBL2397180 IC50 = 12600.0 nM 4.90
CHEMBL127028 IC50 = 14100.0 nM 4.85
CHEMBL2397173 IC50 = 14500.0 nM 4.84