Assay Detail
Binding
CHEMBL2401082
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DPCPX from human recombinant adenosine A1 receptor expressed in CHO-K1 cells after 60 mins
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of metabolites of 2-n-butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine (ST1535), a potent antagonist of the A2A adenosine receptor for the treatment of Parkinson's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.08 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2398484 | — | — | 1 | 7.47 |
| CHEMBL2398482 | — | — | 1 | 7.47 |
| CHEMBL2398483 | — | — | 1 | 7.28 |
| CHEMBL197669 | ST1535 | 1.0 | 1 | 7.00 |
| CHEMBL2398485 | — | — | 1 | 6.82 |
| CHEMBL2398480 | — | — | 1 | 6.80 |
| CHEMBL2398486 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2398484 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL2398482 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL2398483 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL197669 | ST1535 | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL2398485 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL2398480 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL2398486 | — | Ki | = | 200.0 | nM | 6.70 |