Compound Detail
CHEMBL2398484
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Basic Information
| ChEMBL ID | CHEMBL2398484 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HMSFWLUZEDMXMM-SSDOTTSWSA-N |
2
Targets
4
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
288.3
MW (Da)
-0.16
ALogP
9
HBA
2
HBD
120.6
PSA (Ų)
0.68
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 8.12
IC50 1 meas. best 6.38
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Adenosine receptor A2a CHEMBL251 | Ki | 8.12 | 8.11 | 7.5 | 2 |
| Adenosine receptor A1 CHEMBL226 | Ki | 7.47 | 7.47 | 34.0 | 1 |
| Adenosine receptor A2a CHEMBL251 | IC50 | 6.38 | 6.38 | 420.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Adenosine receptor A2a | Ki | = | 7.5 | nM | 8.12 | Displacement of [3H]ZM241385 from human recombinant adenosine A2A receptor expre... | 23789814 |
| Adenosine receptor A2a | Ki | = | 8.0 | nM | 8.1 | Competition Binding Assay: The protein concentration of membrane suspension was ... | - |
| Adenosine receptor A1 | Ki | = | 34.0 | nM | 7.47 | Displacement of [3H]DPCPX from human recombinant adenosine A1 receptor expressed... | 23789814 |
| Adenosine receptor A2a | IC50 | = | 420.0 | nM | 6.38 | Antagonist activity at human adenosine A2A receptor expressed in HEK293 cells as... | 23789814 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23789814 | 10.1021/jm400491x | Adenosine receptor A2a | 2 |
| 23789814 | 10.1021/jm400491x | Adenosine receptor A1 | 1 |
Data from ChEMBL 36 via Core Engine