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Assay Detail

CHEMBL2406170

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Antagonist activity at human Gal4-ERbeta assessed as inhibition of 17beta-estradiol-induced effect by reporter gene assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Estrogen receptor beta (CHEMBL242)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Structure-activity relationships of bisphenol A analogs at estrogen receptors (ERs): discovery of an ERα-selective antagonist.
Maruyama K, Nakamura M, Tomoshige S, Sugita K, Makishima M, Hashimoto Y, Ishikawa M.
Bioorg Med Chem Lett (2013) 23 : 4031 -4036
PubMed 23768907 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 6.35 7.37

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2403348 1 7.37
CHEMBL1782331 1 7.03
CHEMBL2403356 1 6.85
CHEMBL2403357 1 6.82
CHEMBL2403362 1 6.75
CHEMBL2403355 1 6.58
CHEMBL1208076 1 6.57
CHEMBL2403347 1 6.52
CHEMBL2403346 1 6.42
CHEMBL1231453 1 6.25
CHEMBL2403358 1 6.11
CHEMBL2403359 1 6.10
CHEMBL2403349 1 6.10
CHEMBL2403360 1 5.89
CHEMBL2403361 1 5.66
CHEMBL2403363 1 5.58
CHEMBL2403351 1 5.35
CHEMBL2403350 1 -
CHEMBL2403354 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2403348 IC50 = 43.0 nM 7.37
CHEMBL1782331 IC50 = 93.0 nM 7.03
CHEMBL2403356 IC50 = 140.0 nM 6.85
CHEMBL2403357 IC50 = 150.0 nM 6.82
CHEMBL2403362 IC50 = 180.0 nM 6.75
CHEMBL2403355 IC50 = 260.0 nM 6.58
CHEMBL1208076 IC50 = 270.0 nM 6.57
CHEMBL2403347 IC50 = 300.0 nM 6.52
CHEMBL2403346 IC50 = 380.0 nM 6.42
CHEMBL1231453 IC50 = 560.0 nM 6.25
CHEMBL2403358 IC50 = 770.0 nM 6.11
CHEMBL2403359 IC50 = 790.0 nM 6.10
CHEMBL2403349 IC50 = 800.0 nM 6.10
CHEMBL2403360 IC50 = 1300.0 nM 5.89
CHEMBL2403361 IC50 = 2200.0 nM 5.66
CHEMBL2403363 IC50 = 2600.0 nM 5.58
CHEMBL2403351 IC50 = 4500.0 nM 5.35
CHEMBL2403350 IC50 - -
CHEMBL2403354 IC50 - -