Compound Detail
CHEMBL2403349
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL2403349 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OVIZTZNSIRDYRY-UHFFFAOYSA-N |
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
300.5
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 7.53
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Estrogen receptor CHEMBL206 | IC50 | 7.53 | 7.335 | 29.7 | 2 |
| Estrogen receptor beta CHEMBL242 | IC50 | 6.1 | 6.1 | 800.0 | 1 |
| Androgen receptor CHEMBL1871 | IC50 | 5.72 | 5.72 | 1900.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Estrogen receptor | IC50 | = | 29.7 | nM | 7.53 | Antagonist activity at human Gal4-fused ER-alpha expressed in HEK293 cells asses... | 24630694 |
| Estrogen receptor | IC50 | = | 72.0 | nM | 7.14 | Antagonist activity at human Gal4-ERalpha assessed as inhibition of 17beta-estra... | 23768907 |
| Estrogen receptor beta | IC50 | = | 800.0 | nM | 6.1 | Antagonist activity at human Gal4-ERbeta assessed as inhibition of 17beta-estrad... | 23768907 |
| Androgen receptor | IC50 | = | 1900.0 | nM | 5.72 | Antagonist activity at human pSG5-AR assessed as inhibition of dihydrotestostero... | 23768907 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23768907 | 10.1016/j.bmcl.2013.05.067 | Estrogen receptor beta | 2 |
| 23768907 | 10.1016/j.bmcl.2013.05.067 | Estrogen receptor | 2 |
| 23768907 | 10.1016/j.bmcl.2013.05.067 | Androgen receptor | 1 |
| 24630694 | 10.1016/j.bmc.2014.02.025 | Estrogen receptor | 1 |
| 24630694 | 10.1016/j.bmc.2014.02.025 | Estrogen receptor beta | 1 |
Data from ChEMBL 36 via Core Engine