Assay Detail
Binding
CHEMBL3242833
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human Gal4-fused ER-alpha expressed in HEK293 cells assessed as inhibition of 17beta-estradiol-induced effect by luciferase reporter gene assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of silicon-containing steroid sulfatase inhibitors possessing pro-estrogen antagonistic character.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.66 | 8.45 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2403355 | — | — | 1 | 8.45 |
| CHEMBL2403356 | — | — | 1 | 8.31 |
| CHEMBL2403357 | — | — | 1 | 7.85 |
| CHEMBL3235686 | — | — | 1 | 7.58 |
| CHEMBL2403349 | — | — | 1 | 7.53 |
| CHEMBL3235685 | — | — | 1 | 6.94 |
| CHEMBL1782331 | — | — | 1 | 6.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2403355 | — | IC50 | = | 3.53 | nM | 8.45 |
| CHEMBL2403356 | — | IC50 | = | 4.92 | nM | 8.31 |
| CHEMBL2403357 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3235686 | — | IC50 | = | 26.2 | nM | 7.58 |
| CHEMBL2403349 | — | IC50 | = | 29.7 | nM | 7.53 |
| CHEMBL3235685 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL1782331 | — | IC50 | = | 118.0 | nM | 6.93 |