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Assay Detail

CHEMBL2406173

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Agonist activity at human Gal4-ERbeta by reporter gene assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Estrogen receptor beta (CHEMBL242)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Structure-activity relationships of bisphenol A analogs at estrogen receptors (ERs): discovery of an ERα-selective antagonist.
Maruyama K, Nakamura M, Tomoshige S, Sugita K, Makishima M, Hashimoto Y, Ishikawa M.
Bioorg Med Chem Lett (2013) 23 : 4031 -4036
PubMed 23768907 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 20 5.65 5.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL418971 BISPHENOL A 1 5.96
CHEMBL138061 1 5.72
CHEMBL2403354 1 5.26
CHEMBL2403349 1 -
CHEMBL2403348 1 -
CHEMBL2403347 1 -
CHEMBL2403344 1 -
CHEMBL2403353 1 -
CHEMBL2403352 1 -
CHEMBL2403351 1 -
CHEMBL2403363 1 -
CHEMBL2403360 1 -
CHEMBL2403350 1 -
CHEMBL2403358 1 -
CHEMBL2403357 1 -
CHEMBL2403356 1 -
CHEMBL1231453 1 -
CHEMBL1208076 1 -
CHEMBL2403362 1 -
CHEMBL2403359 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL418971 BISPHENOL A EC50 = 1100.0 nM 5.96
CHEMBL138061 EC50 = 1900.0 nM 5.72
CHEMBL2403354 EC50 = 5500.0 nM 5.26
CHEMBL2403349 EC50 - -
CHEMBL2403348 EC50 - -
CHEMBL2403347 EC50 - -
CHEMBL2403344 EC50 - -
CHEMBL2403353 EC50 - -
CHEMBL2403352 EC50 - -
CHEMBL2403351 EC50 - -
CHEMBL2403363 EC50 - -
CHEMBL2403360 EC50 - -
CHEMBL2403350 EC50 - -
CHEMBL2403358 EC50 - -
CHEMBL2403357 EC50 - -
CHEMBL2403356 EC50 - -
CHEMBL1231453 EC50 - -
CHEMBL1208076 EC50 - -
CHEMBL2403362 EC50 - -
CHEMBL2403359 EC50 - -