Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL2406860

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antitrypanosomal activity against Trypanosoma brucei
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma brucei
Confidence 1 — Organism
Curated By Autocuration

Target

Trypanosoma brucei (CHEMBL612849)
Type ORGANISM
Organism Trypanosoma brucei

Publication

Inhibition of rhodesain as a novel therapeutic modality for human African trypanosomiasis.
Ettari R, Tamborini L, Angelo IC, Micale N, Pinto A, De Micheli C, Conti P.
J Med Chem (2013) 56 : 5637 -5658
PubMed 23611656 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 5.44 6.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL73007 1 6.52
CHEMBL326220 1 5.70
CHEMBL109619 1 5.52
CHEMBL108700 1 5.52
CHEMBL109893 1 5.52
CHEMBL107612 1 5.35
CHEMBL108865 1 5.22
CHEMBL111632 1 5.10
CHEMBL323975 1 5.00
CHEMBL108035 1 4.92
CHEMBL2402110 1 -
CHEMBL88734 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL73007 IC50 = 300.0 nM 6.52
CHEMBL326220 IC50 = 2000.0 nM 5.70
CHEMBL109619 IC50 = 3000.0 nM 5.52
CHEMBL108700 IC50 = 3000.0 nM 5.52
CHEMBL109893 IC50 = 3000.0 nM 5.52
CHEMBL107612 IC50 = 4500.0 nM 5.35
CHEMBL108865 IC50 = 6000.0 nM 5.22
CHEMBL111632 IC50 = 8000.0 nM 5.10
CHEMBL323975 IC50 = 10000.0 nM 5.00
CHEMBL108035 IC50 = 12000.0 nM 4.92
CHEMBL2402110 IC50 > 20000.0 nM -
CHEMBL88734 IC50 > 20000.0 nM -