Assay Detail
Binding
CHEMBL2411348
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at estrogen receptor alpha (unknown origin) by NH Pro assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel oxazolidinedione derivatives as potent and selective mineralocorticoid receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.96 | 5.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2407651 | — | — | 1 | 5.14 |
| CHEMBL2407647 | — | — | 1 | 4.77 |
| CHEMBL1095097 | EPLERENONE | 4.0 | 1 | - |
| CHEMBL1393 | SPIRONOLACTONE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2407651 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL2407647 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL1095097 | EPLERENONE | IC50 | > | 20000.0 | nM | - |
| CHEMBL1393 | SPIRONOLACTONE | IC50 | > | 20000.0 | nM | - |