Assay Detail
Functional
CHEMBL2412381
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytoprotective activity against BSO-induced cell death in human Friedreich's ataxia lymphocytes preincubated for 12 hrs prior to BSO-treatment measured after 48 hrs by luminescence assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
An optimized pyrimidinol multifunctional radical quencher.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 6.98 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2408031 | — | — | 1 | 7.66 |
| CHEMBL2408032 | — | — | 1 | 7.60 |
| CHEMBL2408028 | — | — | 1 | 7.50 |
| CHEMBL217894 | DECYLUBIQUINONE | — | 1 | 7.25 |
| CHEMBL2408030 | — | — | 1 | 7.17 |
| CHEMBL2408027 | — | — | 1 | 6.58 |
| CHEMBL2408029 | — | — | 1 | 6.46 |
| CHEMBL2172356 | — | — | 1 | 6.34 |
| CHEMBL252556 | IDEBENONE | 4.0 | 1 | 6.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2408031 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL2408032 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL2408028 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL217894 | DECYLUBIQUINONE | EC50 | = | 56.0 | nM | 7.25 |
| CHEMBL2408030 | — | EC50 | = | 68.0 | nM | 7.17 |
| CHEMBL2408027 | — | EC50 | = | 266.0 | nM | 6.58 |
| CHEMBL2408029 | — | EC50 | = | 345.0 | nM | 6.46 |
| CHEMBL2172356 | — | EC50 | = | 456.0 | nM | 6.34 |
| CHEMBL252556 | IDEBENONE | EC50 | = | 551.0 | nM | 6.26 |