Assay Detail
Functional
CHEMBL2415232
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Cytotoxicity against human DU145 cells assessed as growth inhibition after 72 hrs by MTS assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DU-145 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Anticancer activity and SAR studies of substituted 1,4-naphthoquinones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.23 | 5.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2414138 | — | — | 1 | 5.91 |
| CHEMBL2414136 | — | — | 1 | 5.83 |
| CHEMBL2414129 | — | — | 1 | 5.64 |
| CHEMBL2414137 | — | — | 1 | 5.61 |
| CHEMBL2414134 | — | — | 1 | 5.54 |
| CHEMBL2414128 | — | — | 1 | 5.54 |
| CHEMBL2414127 | — | — | 1 | 5.50 |
| CHEMBL2414133 | — | — | 1 | 5.47 |
| CHEMBL2414132 | — | — | 1 | 5.44 |
| CHEMBL295316 | PLUMBAGIN | 1.0 | 1 | 5.28 |
| CHEMBL84010 | — | — | 1 | 5.26 |
| CHEMBL1631460 | — | — | 1 | 5.22 |
| CHEMBL2414123 | — | — | 1 | 5.09 |
| CHEMBL2414130 | — | — | 1 | 5.09 |
| CHEMBL590 | MENADIONE | 4.0 | 1 | 5.01 |
| CHEMBL2414122 | — | — | 1 | 4.99 |
| CHEMBL55934 | NAPHTHOQUINONE | — | 1 | 4.96 |
| CHEMBL43612 | JUGLONE | — | 1 | 4.93 |
| CHEMBL2414121 | — | — | 1 | 4.85 |
| CHEMBL2414126 | — | — | 1 | 4.84 |
| CHEMBL2414131 | — | — | 1 | 4.82 |
| CHEMBL2414135 | — | — | 1 | 4.71 |
| CHEMBL92659 | — | — | 1 | 4.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2414138 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL2414136 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL2414129 | — | IC50 | = | 2270.0 | nM | 5.64 |
| CHEMBL2414137 | — | IC50 | = | 2440.0 | nM | 5.61 |
| CHEMBL2414134 | — | IC50 | = | 2850.0 | nM | 5.54 |
| CHEMBL2414128 | — | IC50 | = | 2850.0 | nM | 5.54 |
| CHEMBL2414127 | — | IC50 | = | 3130.0 | nM | 5.50 |
| CHEMBL2414133 | — | IC50 | = | 3370.0 | nM | 5.47 |
| CHEMBL2414132 | — | IC50 | = | 3620.0 | nM | 5.44 |
| CHEMBL295316 | PLUMBAGIN | IC50 | = | 5230.0 | nM | 5.28 |
| CHEMBL84010 | — | IC50 | = | 5520.0 | nM | 5.26 |
| CHEMBL1631460 | — | IC50 | = | 6020.0 | nM | 5.22 |
| CHEMBL2414123 | — | IC50 | = | 8160.0 | nM | 5.09 |
| CHEMBL2414130 | — | IC50 | = | 8120.0 | nM | 5.09 |
| CHEMBL590 | MENADIONE | IC50 | = | 9860.0 | nM | 5.01 |
| CHEMBL2414122 | — | IC50 | = | 10280.0 | nM | 4.99 |
| CHEMBL55934 | NAPHTHOQUINONE | IC50 | = | 10890.0 | nM | 4.96 |
| CHEMBL43612 | JUGLONE | IC50 | = | 11670.0 | nM | 4.93 |
| CHEMBL2414121 | — | IC50 | = | 14220.0 | nM | 4.85 |
| CHEMBL2414126 | — | IC50 | = | 14390.0 | nM | 4.84 |
| CHEMBL2414131 | — | IC50 | = | 15160.0 | nM | 4.82 |
| CHEMBL2414135 | — | IC50 | = | 19500.0 | nM | 4.71 |
| CHEMBL92659 | — | IC50 | = | 22300.0 | nM | 4.65 |