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Assay Detail

CHEMBL2416121

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Binding
Binding affinity to human Hsp90 by surface plasmon resonance analysis
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Heat shock protein HSP 90-beta (CHEMBL4303)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Dimeric and trimeric triazole based molecules as a new class of Hsp90 molecular chaperone inhibitors.
Terracciano S, Chini MG, Piaz FD, Vassallo A, Riccio R, Bruno I, Bifulco G.
Eur J Med Chem (2013) 65 : 464 -476
PubMed 23770448 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 25 7.46 8.66

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL414883 RADICICOL 1 8.66
CHEMBL2413569 1 8.55
CHEMBL2413570 1 8.46
CHEMBL2413568 1 8.44
CHEMBL2413571 1 7.99
CHEMBL2413565 1 7.26
CHEMBL2413566 1 7.14
CHEMBL2413587 1 7.08
CHEMBL2413581 1 7.05
CHEMBL2413580 1 6.97
CHEMBL2413579 1 6.82
CHEMBL2413586 1 6.72
CHEMBL2413582 1 6.70
CHEMBL2413573 1 6.62
CHEMBL2413584 1 -
CHEMBL2413585 1 -
CHEMBL2413567 1 -
CHEMBL2413583 1 -
CHEMBL2413572 1 -
CHEMBL2413084 1 -
CHEMBL2413574 1 -
CHEMBL2413575 1 -
CHEMBL2413576 1 -
CHEMBL2413577 1 -
CHEMBL2413578 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL414883 RADICICOL Kd = 2.2 nM 8.66
CHEMBL2413569 Kd = 2.8 nM 8.55
CHEMBL2413570 Kd = 3.5 nM 8.46
CHEMBL2413568 Kd = 3.6 nM 8.44
CHEMBL2413571 Kd = 10.3 nM 7.99
CHEMBL2413565 Kd = 55.0 nM 7.26
CHEMBL2413566 Kd = 72.0 nM 7.14
CHEMBL2413587 Kd = 84.0 nM 7.08
CHEMBL2413581 Kd = 89.0 nM 7.05
CHEMBL2413580 Kd = 107.0 nM 6.97
CHEMBL2413579 Kd = 151.0 nM 6.82
CHEMBL2413586 Kd = 191.0 nM 6.72
CHEMBL2413582 Kd = 201.0 nM 6.70
CHEMBL2413573 Kd = 237.0 nM 6.62
CHEMBL2413584 Kd - -
CHEMBL2413585 Kd - -
CHEMBL2413567 Kd - -
CHEMBL2413583 Kd - -
CHEMBL2413572 Kd - -
CHEMBL2413084 Kd - -
CHEMBL2413574 Kd - -
CHEMBL2413575 Kd - -
CHEMBL2413576 Kd - -
CHEMBL2413577 Kd - -
CHEMBL2413578 Kd - -