Assay Detail
Binding
CHEMBL2416839
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Inhibition of horse serum BChE using acetylthiocholine iodide as substrate preincubated for 5 mins before substrate addition by Ellman's method
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, biological activity and molecular modeling studies on 1H-benzimidazole derivatives as acetylcholinesterase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.50 | 8.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95 | TACRINE | 4.0 | 1 | 8.01 |
| CHEMBL2413736 | — | — | 1 | 5.86 |
| CHEMBL2413560 | — | — | 1 | 5.61 |
| CHEMBL2413735 | — | — | 1 | 5.49 |
| CHEMBL2413742 | — | — | 1 | 5.47 |
| CHEMBL2413558 | — | — | 1 | 5.39 |
| CHEMBL377740 | — | — | 1 | 5.34 |
| CHEMBL2413732 | — | — | 1 | 5.33 |
| CHEMBL2413745 | — | — | 1 | 5.30 |
| CHEMBL2413746 | — | — | 1 | 5.23 |
| CHEMBL2413734 | — | — | 1 | 5.19 |
| CHEMBL2413741 | — | — | 1 | 5.13 |
| CHEMBL2413738 | — | — | 1 | 5.07 |
| CHEMBL2413559 | — | — | 1 | 4.64 |
| CHEMBL2413737 | — | — | 1 | - |
| CHEMBL2413739 | — | — | 1 | - |
| CHEMBL2413740 | — | — | 1 | - |
| CHEMBL2413733 | — | — | 1 | - |
| CHEMBL2413561 | — | — | 1 | - |
| CHEMBL2413743 | — | — | 1 | - |
| CHEMBL2413744 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95 | TACRINE | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL2413736 | — | IC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL2413560 | — | IC50 | = | 2450.0 | nM | 5.61 |
| CHEMBL2413735 | — | IC50 | = | 3240.0 | nM | 5.49 |
| CHEMBL2413742 | — | IC50 | = | 3420.0 | nM | 5.47 |
| CHEMBL2413558 | — | IC50 | = | 4110.0 | nM | 5.39 |
| CHEMBL377740 | — | IC50 | = | 4590.0 | nM | 5.34 |
| CHEMBL2413732 | — | IC50 | = | 4670.0 | nM | 5.33 |
| CHEMBL2413745 | — | IC50 | = | 5060.0 | nM | 5.30 |
| CHEMBL2413746 | — | IC50 | = | 5870.0 | nM | 5.23 |
| CHEMBL2413734 | — | IC50 | = | 6480.0 | nM | 5.19 |
| CHEMBL2413741 | — | IC50 | = | 7440.0 | nM | 5.13 |
| CHEMBL2413738 | — | IC50 | = | 8520.0 | nM | 5.07 |
| CHEMBL2413559 | — | IC50 | = | 23050.0 | nM | 4.64 |
| CHEMBL2413737 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2413739 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2413740 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2413733 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2413561 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2413743 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2413744 | — | IC50 | > | 100000.0 | nM | - |