Assay Detail
Functional
CHEMBL2422600
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Antiviral activity against thymidine kinase positive Varicella-zoster virus OKA infected in human HEL cells assessed as reduction in virus plaque formation
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human herpesvirus 3 strain Oka vaccine |
| Cell Type | HEL |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Regioselective synthesis of 6-substituted-2-amino-5-bromo-4(3H)-pyrimidinones and evaluation of their antiviral activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 5.40 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL31634 | BRIVUDINE | 2.0 | 1 | 7.70 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 5.68 |
| CHEMBL2420195 | — | — | 1 | 5.60 |
| CHEMBL2420193 | — | — | 1 | 4.00 |
| CHEMBL2420192 | — | — | 1 | 4.00 |
| CHEMBL2420196 | — | — | 1 | - |
| CHEMBL2420194 | — | — | 1 | - |
| CHEMBL2420191 | — | — | 1 | - |
| CHEMBL2420188 | — | — | 1 | - |
| CHEMBL2420189 | — | — | 1 | - |
| CHEMBL2420190 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL31634 | BRIVUDINE | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL184 | ACYCLOVIR | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL2420195 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL2420193 | — | EC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL2420192 | — | EC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL2420196 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2420194 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2420191 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2420188 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2420189 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL2420190 | — | EC50 | > | 4000.0 | nM | - |