Assay Detail
Functional
CHEMBL2422881
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against wild type HIV1 3B infected in human MT2 cells assessed as protection against virus-induced effect by MTT assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Optimization of diarylazines as anti-HIV agents with dramatically enhanced solubility.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 8.34 | 9.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2418595 | — | — | 1 | 9.72 |
| CHEMBL175691 | RILPIVIRINE | 4.0 | 1 | 9.17 |
| CHEMBL70663 | DAPIVIRINE | 3.0 | 1 | 9.15 |
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 9.00 |
| CHEMBL2418594 | — | — | 1 | 8.92 |
| CHEMBL2418596 | — | — | 1 | 8.80 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 8.70 |
| CHEMBL2418597 | — | — | 1 | 8.66 |
| CHEMBL71728 | — | — | 1 | 8.64 |
| CHEMBL2418598 | — | — | 1 | 8.55 |
| CHEMBL2418599 | — | — | 1 | 8.30 |
| CHEMBL2418593 | — | — | 1 | 8.17 |
| CHEMBL2418592 | — | — | 1 | 8.09 |
| CHEMBL2418590 | — | — | 1 | 8.07 |
| CHEMBL2418591 | — | — | 1 | 7.92 |
| CHEMBL2418589 | — | — | 1 | 7.72 |
| CHEMBL2418600 | — | — | 1 | 7.62 |
| CHEMBL2418601 | — | — | 1 | 7.62 |
| CHEMBL2418602 | — | — | 1 | 7.04 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 6.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2418595 | — | EC50 | = | 0.19 | nM | 9.72 |
| CHEMBL175691 | RILPIVIRINE | EC50 | = | 0.67 | nM | 9.17 |
| CHEMBL70663 | DAPIVIRINE | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL308954 | ETRAVIRINE | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2418594 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL2418596 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2418597 | — | EC50 | = | 2.2 | nM | 8.66 |
| CHEMBL71728 | — | EC50 | = | 2.3 | nM | 8.64 |
| CHEMBL2418598 | — | EC50 | = | 2.8 | nM | 8.55 |
| CHEMBL2418599 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2418593 | — | EC50 | = | 6.8 | nM | 8.17 |
| CHEMBL2418592 | — | EC50 | = | 8.1 | nM | 8.09 |
| CHEMBL2418590 | — | EC50 | = | 8.6 | nM | 8.07 |
| CHEMBL2418591 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2418589 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL2418600 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL2418601 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL2418602 | — | EC50 | = | 92.0 | nM | 7.04 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 110.0 | nM | 6.96 |