Assay Detail
Functional
CHEMBL2422883
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 3B harboring reverse transcriptase Y181C mutant infected in human MT2 cells assessed as protection against virus-induced effect by MTT assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Optimization of diarylazines as anti-HIV agents with dramatically enhanced solubility.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 6.83 | 9.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL175691 | RILPIVIRINE | 4.0 | 1 | 9.19 |
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 8.10 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 8.00 |
| CHEMBL2418594 | — | — | 1 | 7.92 |
| CHEMBL70663 | DAPIVIRINE | 3.0 | 1 | 7.41 |
| CHEMBL71728 | — | — | 1 | 7.33 |
| CHEMBL2418599 | — | — | 1 | 6.64 |
| CHEMBL2418597 | — | — | 1 | 6.57 |
| CHEMBL2418592 | — | — | 1 | 6.51 |
| CHEMBL2418595 | — | — | 1 | 6.46 |
| CHEMBL2418590 | — | — | 1 | 6.32 |
| CHEMBL2418596 | — | — | 1 | 6.30 |
| CHEMBL2418589 | — | — | 1 | 6.16 |
| CHEMBL2418591 | — | — | 1 | 6.16 |
| CHEMBL2418593 | — | — | 1 | 6.00 |
| CHEMBL2418600 | — | — | 1 | 6.00 |
| CHEMBL2418598 | — | — | 1 | 5.96 |
| CHEMBL2418601 | — | — | 1 | 5.92 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL175691 | RILPIVIRINE | EC50 | = | 0.65 | nM | 9.19 |
| CHEMBL308954 | ETRAVIRINE | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2418594 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL70663 | DAPIVIRINE | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL71728 | — | EC50 | = | 47.0 | nM | 7.33 |
| CHEMBL2418599 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL2418597 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL2418592 | — | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL2418595 | — | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL2418590 | — | EC50 | = | 480.0 | nM | 6.32 |
| CHEMBL2418596 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2418589 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL2418591 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL2418593 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2418600 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2418598 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL2418601 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL57 | NEVIRAPINE | EC50 | - | — | - |