Assay Detail
Functional
CHEMBL2423055
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against TK-positive Varicella-zoster virus OKA infected in human HEL cells assessed as reduction of plaque formation
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 3 |
| Cell Type | HEL |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of 4-aminoquinoline-pyrimidine hybrids as potent antimalarials and their mode of action studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 6.13 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 7.58 |
| CHEMBL31634 | BRIVUDINE | 2.0 | 1 | 5.42 |
| CHEMBL2418399 | — | — | 1 | 5.40 |
| CHEMBL2418404 | — | — | 1 | - |
| CHEMBL2418403 | — | — | 1 | - |
| CHEMBL2418402 | — | — | 1 | - |
| CHEMBL2418401 | — | — | 1 | - |
| CHEMBL2418400 | — | — | 1 | - |
| CHEMBL2418398 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL184 | ACYCLOVIR | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL31634 | BRIVUDINE | EC50 | = | 3820.0 | nM | 5.42 |
| CHEMBL2418399 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL2418404 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL2418403 | — | EC50 | > | 4000.0 | nM | - |
| CHEMBL2418402 | — | EC50 | > | 4000.0 | nM | - |
| CHEMBL2418401 | — | EC50 | > | 4000.0 | nM | - |
| CHEMBL2418400 | — | EC50 | > | 4000.0 | nM | - |
| CHEMBL2418398 | — | EC50 | > | 4000.0 | nM | - |