Assay Detail
Binding
CHEMBL2423499
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CYP11B1 expressed in hamster V79MZh cells using [1,2-3H]-11-deoxycorticosterone as substrate
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | V79MZh |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Cushing's syndrome: development of highly potent and selective CYP11B1 inhibitors of the (pyridylmethyl)pyridine type.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 7.27 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2417616 | — | — | 1 | 8.89 |
| CHEMBL2417553 | — | — | 1 | 8.70 |
| CHEMBL2417614 | — | — | 1 | 8.30 |
| CHEMBL2417635 | — | — | 1 | 8.22 |
| CHEMBL2417637 | — | — | 1 | 8.10 |
| CHEMBL2417626 | — | — | 1 | 7.96 |
| CHEMBL2417622 | — | — | 1 | 7.92 |
| CHEMBL934 | METYRAPONE | 4.0 | 1 | 7.82 |
| CHEMBL2417621 | — | — | 1 | 7.68 |
| CHEMBL2417625 | — | — | 1 | 7.68 |
| CHEMBL2417620 | — | — | 1 | 7.55 |
| CHEMBL2417633 | — | — | 1 | 7.50 |
| CHEMBL2417619 | — | — | 1 | 7.48 |
| CHEMBL2417613 | — | — | 1 | 7.42 |
| CHEMBL2417615 | — | — | 1 | 7.29 |
| CHEMBL2417627 | — | — | 1 | 7.22 |
| CHEMBL2011253 | — | — | 1 | 7.17 |
| CHEMBL2417623 | — | — | 1 | 7.16 |
| CHEMBL2417632 | — | — | 1 | 7.06 |
| CHEMBL2417634 | — | — | 1 | 7.01 |
| CHEMBL428780 | — | — | 1 | 6.97 |
| CHEMBL2417624 | — | — | 1 | 6.91 |
| CHEMBL2417612 | — | — | 1 | 6.90 |
| CHEMBL2417628 | — | — | 1 | 6.82 |
| CHEMBL2011262 | — | — | 1 | 6.74 |
| CHEMBL2417636 | — | — | 1 | 6.62 |
| CHEMBL2417638 | — | — | 1 | 6.37 |
| CHEMBL2417630 | — | — | 1 | 6.21 |
| CHEMBL2417617 | — | — | 1 | 5.99 |
| CHEMBL2417631 | — | — | 1 | 5.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2417616 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL2417553 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2417614 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2417635 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2417637 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2417626 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2417622 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL934 | METYRAPONE | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2417621 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL2417625 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL2417620 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL2417633 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL2417619 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL2417613 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL2417615 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL2417627 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL2011253 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL2417623 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL2417632 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL2417634 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL428780 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL2417624 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL2417612 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL2417628 | — | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL2011262 | — | IC50 | = | 181.0 | nM | 6.74 |
| CHEMBL2417636 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL2417638 | — | IC50 | = | 427.0 | nM | 6.37 |
| CHEMBL2417630 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL2417617 | — | IC50 | = | 1015.0 | nM | 5.99 |
| CHEMBL2417631 | — | IC50 | = | 1122.0 | nM | 5.95 |
| CHEMBL2417629 | — | IC50 | = | 1711.0 | nM | 5.77 |
| CHEMBL2417618 | — | IC50 | > | 5000.0 | nM | - |