Assay Detail
Functional
CHEMBL2423679
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Antiproliferative activity against human A2780 cells assessed as growth inhibition after 72 hrs by SRB-based microplate reader analysis
60
Total Activities
60
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-based discovery of novel amide-containing nicotinamide phosphoribosyltransferase (nampt) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 60 | 7.83 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2420628 | — | — | 1 | 9.00 |
| CHEMBL2420627 | — | — | 1 | 9.00 |
| CHEMBL2420625 | — | — | 1 | 9.00 |
| CHEMBL2420622 | — | — | 1 | 9.00 |
| CHEMBL566757 | DAPORINAD | 2.0 | 1 | 9.00 |
| CHEMBL2420631 | — | — | 1 | 9.00 |
| CHEMBL2420633 | — | — | 1 | 8.70 |
| CHEMBL2420630 | — | — | 1 | 8.70 |
| CHEMBL2420629 | — | — | 1 | 8.70 |
| CHEMBL2420626 | — | — | 1 | 8.70 |
| CHEMBL2420634 | — | — | 1 | 8.70 |
| CHEMBL2420632 | — | — | 1 | 8.52 |
| CHEMBL2420624 | — | — | 1 | 8.52 |
| CHEMBL2420649 | — | — | 1 | 8.52 |
| CHEMBL2420647 | — | — | 1 | 8.40 |
| CHEMBL17289 | CHS-828 | 1.0 | 1 | 8.30 |
| CHEMBL2420620 | — | — | 1 | 8.30 |
| CHEMBL2420658 | — | — | 1 | 8.22 |
| CHEMBL2420666 | — | — | 1 | 8.22 |
| CHEMBL2420623 | — | — | 1 | 8.05 |
| CHEMBL2419504 | — | — | 1 | 8.05 |
| CHEMBL2420670 | — | — | 1 | 8.00 |
| CHEMBL2420651 | — | — | 1 | 7.96 |
| CHEMBL2420646 | — | — | 1 | 7.89 |
| CHEMBL2420667 | — | — | 1 | 7.89 |
| CHEMBL2420619 | — | — | 1 | 7.85 |
| CHEMBL2420659 | — | — | 1 | 7.85 |
| CHEMBL2420618 | — | — | 1 | 7.80 |
| CHEMBL2419503 | — | — | 1 | 7.75 |
| CHEMBL2420648 | — | — | 1 | 7.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2420628 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2420631 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL566757 | DAPORINAD | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2420622 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2420627 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2420625 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2420633 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2420630 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2420629 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2420626 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2420634 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2420632 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2420624 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2420649 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2420647 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL17289 | CHS-828 | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2420620 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2420658 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2420666 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2420623 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL2419504 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL2420670 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2420651 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2420646 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2420667 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2420619 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2420659 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2420618 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL2419503 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL2420648 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL2420650 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL2420657 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL2420621 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL2420638 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL2420637 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL2420656 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2420660 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL2420673 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL2420655 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL2420652 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL2420672 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL2420653 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2420661 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2420654 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2420669 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2420671 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2420645 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2420662 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2420663 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2420664 | — | IC50 | > | 10000.0 | nM | - |