Assay Detail
ADMET
CHEMBL2424022
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Inhibition of human recombinant CYP3A4
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Lead optimization of ethyl 6-aminonicotinate acyl sulfonamides as antagonists of the P2Y12 receptor. separation of the antithrombotic effect and bleeding for candidate drug AZD1283.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.22 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2419495 | — | — | 1 | 5.85 |
| CHEMBL2419485 | — | — | 1 | 5.48 |
| CHEMBL2419491 | — | — | 1 | 5.35 |
| CHEMBL2419490 | — | — | 1 | 4.70 |
| CHEMBL2419487 | — | — | 1 | 4.70 |
| CHEMBL2419494 | — | — | 1 | - |
| CHEMBL2419493 | — | — | 1 | - |
| CHEMBL2419492 | — | — | 1 | - |
| CHEMBL2419486 | — | — | 1 | - |
| CHEMBL2419501 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2419495 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL2419485 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL2419491 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL2419490 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL2419487 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL2419494 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL2419493 | — | IC50 | > | 17000.0 | nM | - |
| CHEMBL2419492 | — | IC50 | > | 17000.0 | nM | - |
| CHEMBL2419486 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL2419501 | — | IC50 | > | 50000.0 | nM | - |