Assay Detail
Binding
CHEMBL2427726
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Displacement of [3H]-raclopride from dopamine D2 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis
22
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
2,3,9- and 2,3,11-trisubstituted tetrahydroprotoberberines as D2 dopaminergic ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 6.14 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2425378 | — | — | 2 | 7.55 |
| CHEMBL2425371 | — | — | 2 | 7.13 |
| CHEMBL2425376 | — | — | 2 | 7.07 |
| CHEMBL2425369 | — | — | 2 | 6.73 |
| CHEMBL2425374 | — | — | 2 | 6.44 |
| CHEMBL2425375 | — | — | 2 | 6.41 |
| CHEMBL2425372 | — | — | 2 | 5.94 |
| CHEMBL2425368 | — | — | 2 | 5.70 |
| CHEMBL2425373 | — | — | 2 | 5.29 |
| CHEMBL2425377 | — | — | 2 | 5.16 |
| CHEMBL2425370 | — | — | 2 | 4.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2425378 | — | Ki | = | 28.18 | nM | 7.55 |
| CHEMBL2425378 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL2425371 | — | Ki | = | 74.13 | nM | 7.13 |
| CHEMBL2425371 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL2425376 | — | Ki | = | 85.11 | nM | 7.07 |
| CHEMBL2425376 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL2425369 | — | Ki | = | 188.0 | nM | 6.73 |
| CHEMBL2425369 | — | Ki | = | 186.21 | nM | 6.73 |
| CHEMBL2425374 | — | Ki | = | 363.08 | nM | 6.44 |
| CHEMBL2425375 | — | Ki | = | 389.05 | nM | 6.41 |
| CHEMBL2425374 | — | Ki | = | 393.0 | nM | 6.41 |
| CHEMBL2425375 | — | Ki | = | 396.0 | nM | 6.40 |
| CHEMBL2425372 | — | Ki | = | 1148.15 | nM | 5.94 |
| CHEMBL2425372 | — | Ki | = | 1331.0 | nM | 5.88 |
| CHEMBL2425368 | — | Ki | = | 1995.26 | nM | 5.70 |
| CHEMBL2425368 | — | Ki | = | 2046.0 | nM | 5.69 |
| CHEMBL2425373 | — | Ki | = | 5128.61 | nM | 5.29 |
| CHEMBL2425377 | — | Ki | = | 6918.31 | nM | 5.16 |
| CHEMBL2425377 | — | Ki | = | 7506.0 | nM | 5.12 |
| CHEMBL2425373 | — | Ki | = | 8543.0 | nM | 5.07 |
| CHEMBL2425370 | — | Ki | = | 40866.0 | nM | 4.39 |
| CHEMBL2425370 | — | Ki | = | 41686.94 | nM | 4.38 |