Assay Detail
Binding
CHEMBL2428110
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of spleen tyrosine kinase (unknown origin)
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Spleen |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibitors of switch kinase 'spleen tyrosine kinase' in inflammation and immune-mediated disorders: a review.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 6.49 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL104333 | — | — | 1 | 8.30 |
| CHEMBL287478 | — | — | 1 | 8.10 |
| CHEMBL508339 | — | — | 1 | 7.64 |
| CHEMBL515757 | — | — | 1 | 7.52 |
| CHEMBL471901 | — | — | 1 | 7.39 |
| CHEMBL472611 | — | — | 1 | 7.33 |
| CHEMBL30548 | — | — | 1 | 7.14 |
| CHEMBL30824 | — | — | 1 | 7.11 |
| CHEMBL33626 | — | — | 1 | 6.92 |
| CHEMBL475371 | — | — | 1 | 6.82 |
| CHEMBL31141 | — | — | 1 | 6.80 |
| CHEMBL30514 | — | — | 1 | 6.70 |
| CHEMBL30355 | — | — | 1 | 6.70 |
| CHEMBL281108 | — | — | 1 | 6.68 |
| CHEMBL474361 | — | — | 1 | 6.64 |
| CHEMBL281696 | — | — | 1 | 6.39 |
| CHEMBL33009 | — | — | 1 | 6.38 |
| CHEMBL471753 | — | — | 1 | 6.12 |
| CHEMBL30823 | — | — | 1 | 6.05 |
| CHEMBL30642 | — | — | 1 | 6.05 |
| CHEMBL2426223 | — | — | 1 | 6.03 |
| CHEMBL30388 | — | — | 1 | 5.82 |
| CHEMBL281078 | — | — | 1 | 5.77 |
| CHEMBL281965 | — | — | 1 | 5.44 |
| CHEMBL105421 | — | — | 1 | 5.09 |
| CHEMBL281015 | — | — | 1 | 5.07 |
| CHEMBL69863 | PICEATANNOL | — | 1 | 5.00 |
| CHEMBL33175 | — | — | 1 | 4.60 |
| CHEMBL322153 | — | — | 1 | - |
| CHEMBL2426222 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL104333 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL287478 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL508339 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL515757 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL471901 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL472611 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL30548 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL30824 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL33626 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL475371 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL31141 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL30514 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL30355 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL281108 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL474361 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL281696 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL33009 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL471753 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL30823 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL30642 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL2426223 | — | IC50 | = | 937.0 | nM | 6.03 |
| CHEMBL30388 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL281078 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL281965 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL105421 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL281015 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL69863 | PICEATANNOL | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL33175 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL322153 | — | IC50 | - | — | - | |
| CHEMBL2426222 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2426221 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2426220 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL474652 | — | IC50 | > | 10000.0 | nM | - |