Compound Detail
CHEMBL472611
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Basic Information
| ChEMBL ID | CHEMBL472611 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FXFUDZRQTGOJSU-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
368.4
MW (Da)
2.49
ALogP
6
HBA
4
HBD
119.0
PSA (Ų)
0.53
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.33
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tyrosine-protein kinase SYK CHEMBL2599 | IC50 | 7.33 | 7.33 | 47.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase SYK | IC50 | = | 47.0 | nM | 7.33 | Inhibition of recombinant Syk | 19254842 |
| Tyrosine-protein kinase SYK | IC50 | = | 47.0 | nM | 7.33 | Inhibition of spleen tyrosine kinase (unknown origin) | 23917087 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19254842 | 10.1016/j.bmcl.2009.02.049 | Tyrosine-protein kinase SYK | 1 |
| 23917087 | 10.1016/j.ejmech.2013.04.070 | Tyrosine-protein kinase SYK | 1 |
Data from ChEMBL 36 via Core Engine