Assay Detail
Binding
CHEMBL1022010
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Inhibition of recombinant Syk
141
Total Activities
141
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Pharmacophore modeling study based on known spleen tyrosine kinase inhibitors together with virtual screening for identifying novel inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 141 | 6.36 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL471948 | — | — | 1 | 9.00 |
| CHEMBL515910 | — | — | 1 | 8.80 |
| CHEMBL504558 | — | — | 1 | 8.60 |
| CHEMBL388978 | STAUROSPORINE | — | 1 | 8.52 |
| CHEMBL516061 | — | — | 1 | 8.43 |
| CHEMBL475575 | — | — | 1 | 8.40 |
| CHEMBL474654 | — | — | 1 | 8.40 |
| CHEMBL474655 | — | — | 1 | 8.22 |
| CHEMBL474832 | — | — | 1 | 8.15 |
| CHEMBL473229 | — | — | 1 | 8.05 |
| CHEMBL514012 | — | — | 1 | 8.05 |
| CHEMBL474582 | — | — | 1 | 8.05 |
| CHEMBL475609 | — | — | 1 | 8.05 |
| CHEMBL475780 | — | — | 1 | 7.95 |
| CHEMBL282342 | — | — | 1 | 7.72 |
| CHEMBL475248 | — | — | 1 | 7.68 |
| CHEMBL475249 | — | — | 1 | 7.66 |
| CHEMBL508339 | — | — | 1 | 7.64 |
| CHEMBL475254 | — | — | 1 | 7.58 |
| CHEMBL475250 | — | — | 1 | 7.52 |
| CHEMBL515757 | — | — | 1 | 7.52 |
| CHEMBL107061 | — | — | 1 | 7.50 |
| CHEMBL471727 | — | — | 1 | 7.50 |
| CHEMBL30678 | — | — | 1 | 7.47 |
| CHEMBL284590 | — | — | 1 | 7.47 |
| CHEMBL475251 | R-406 | 2.0 | 1 | 7.39 |
| CHEMBL471901 | — | — | 1 | 7.39 |
| CHEMBL30708 | — | — | 1 | 7.37 |
| CHEMBL472611 | — | — | 1 | 7.33 |
| CHEMBL515756 | — | — | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL471948 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL515910 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL504558 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL516061 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL474654 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL475575 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL474655 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL474832 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL473229 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL514012 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL474582 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL475609 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL475780 | — | IC50 | = | 11.2 | nM | 7.95 |
| CHEMBL282342 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL475248 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL475249 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL508339 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL475254 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL475250 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL515757 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL471727 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL107061 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL284590 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL30678 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL471901 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL475251 | R-406 | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL30708 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL472611 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL515756 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL512328 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL453217 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL105427 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL33466 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL470528 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL285889 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL471585 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL30548 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL506448 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL30873 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL454012 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL322368 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL471776 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL500086 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL471950 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL322152 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL284675 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL318079 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL475371 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL31141 | — | IC50 | = | 160.0 | nM | 6.80 |