Compound Detail
CHEMBL282342
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL282342 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SBGMPUIVPOGTGN-UHFFFAOYSA-N |
4
Targets
6
Activities
2
Assay Types
0
PK Parameters
20
Publications
0
Known Names
Molecular Properties
335.5
MW (Da)
3.51
ALogP
5
HBA
2
HBD
67.1
PSA (Ų)
0.65
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 7.72
Kd 2 meas. best 6.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tyrosine-protein kinase SYK CHEMBL2599 | IC50 | 7.72 | 7.72 | 19.0 | 3 |
| Lysine--tRNA ligase CHEMBL5575 | IC50 | 7.47 | 7.47 | 34.0 | 1 |
| Tyrosine-protein kinase TXK CHEMBL4367 | Kd | 6.4 | 6.4 | 395.0 | 1 |
| STE20-like serine/threonine-protein kinase CHEMBL4202 | Kd | 6.21 | 6.21 | 623.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase SYK | IC50 | = | 19.0 | nM | 7.72 | Inhibitory activity against spleen tyrosine kinase (SYK) | 12668002 |
| Tyrosine-protein kinase SYK | IC50 | = | 19.0 | nM | 7.72 | Inhibition of recombinant Syk | 19254842 |
| Tyrosine-protein kinase SYK | IC50 | = | 19.0 | nM | 7.72 | Inhibition of SYK | 22257213 |
| Lysine--tRNA ligase | IC50 | = | 34.0 | nM | 7.47 | Inhibition of SYK | 19035792 |
| Tyrosine-protein kinase TXK | Kd | = | 395.0 | nM | 6.4 | Binding affinity to human TXK | 19035792 |
| STE20-like serine/threonine-protein kinase | Kd | = | 623.0 | nM | 6.21 | Binding affinity to human SLK | 19035792 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19035792 | 10.1021/jm8011036 | Unchecked | 8 |
| 19035792 | 10.1021/jm8011036 | Tyrosine-protein kinase TXK | 2 |
| 19035792 | 10.1021/jm8011036 | Mitogen-activated protein kinase kinase kinase kinase 4 | 2 |
| 19035792 | 10.1021/jm8011036 | Atypical kinase COQ8B, mitochondrial | 2 |
| 19035792 | 10.1021/jm8011036 | Ribosomal protein S6 kinase alpha-4 | 2 |
| 19035792 | 10.1021/jm8011036 | Lysine--tRNA ligase | 2 |
| 19035792 | 10.1021/jm8011036 | STE20-like serine/threonine-protein kinase | 2 |
| 19035792 | 10.1021/jm8011036 | RAC-alpha serine/threonine-protein kinase | 1 |
| 19035792 | 10.1021/jm8011036 | RAC-beta serine/threonine-protein kinase | 1 |
| 19035792 | 10.1021/jm8011036 | RAC-gamma serine/threonine-protein kinase | 1 |
| 19035792 | 10.1021/jm8011036 | Protein kinase C alpha type | 1 |
| 19254842 | 10.1016/j.bmcl.2009.02.049 | Tyrosine-protein kinase SYK | 1 |
| 19035792 | 10.1021/jm8011036 | Serine/threonine-protein kinase N2 | 1 |
| 19035792 | 10.1021/jm8011036 | Ribosomal protein S6 kinase alpha-5 | 1 |
| 19035792 | 10.1021/jm8011036 | Ribosomal protein S6 kinase alpha-1 | 1 |
| 19035792 | 10.1021/jm8011036 | Ribosomal protein S6 kinase alpha-3 | 1 |
| 19035792 | 10.1021/jm8011036 | cAMP-dependent protein kinase catalytic subunit PRKX | 1 |
| 22257213 | 10.1021/jm201271b | Tyrosine-protein kinase SYK | 1 |
| 19035792 | 10.1021/jm8011036 | Serine/threonine-protein kinase MRCK alpha | 1 |
| 19035792 | 10.1021/jm8011036 | Myotonin-protein kinase | 1 |
Data from ChEMBL 36 via Core Engine