Assay Detail
Binding
CHEMBL2173408
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Inhibition of SYK
44
Total Activities
44
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery and development of spleen tyrosine kinase (SYK) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 6.46 | 8.40 |
| Ki | 7 | 7.36 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2170582 | R-343 | 2.0 | 1 | 8.74 |
| CHEMBL1235110 | — | — | 1 | 8.40 |
| CHEMBL1190711 | — | — | 1 | 8.12 |
| CHEMBL287478 | — | — | 1 | 8.10 |
| CHEMBL2170585 | — | — | 1 | 8.00 |
| CHEMBL431645 | — | — | 1 | 7.92 |
| CHEMBL104279 | — | — | 1 | 7.85 |
| CHEMBL282342 | — | — | 1 | 7.72 |
| CHEMBL104519 | — | — | 1 | 7.70 |
| CHEMBL475251 | R-406 | 2.0 | 1 | 7.52 |
| CHEMBL107061 | — | — | 1 | 7.50 |
| CHEMBL30678 | — | — | 1 | 7.47 |
| CHEMBL30548 | — | — | 1 | 7.14 |
| CHEMBL30824 | — | — | 1 | 7.11 |
| CHEMBL30873 | — | — | 1 | 7.05 |
| CHEMBL515271 | R-112 | 2.0 | 1 | 7.02 |
| CHEMBL284675 | — | — | 1 | 6.85 |
| CHEMBL318079 | — | — | 1 | 6.84 |
| CHEMBL31141 | — | — | 1 | 6.80 |
| CHEMBL56904 | — | — | 1 | 6.80 |
| CHEMBL30826 | — | — | 1 | 6.72 |
| CHEMBL30355 | — | — | 1 | 6.70 |
| CHEMBL285346 | — | — | 1 | 6.58 |
| CHEMBL285916 | — | — | 1 | 6.58 |
| CHEMBL104813 | — | — | 1 | 6.56 |
| CHEMBL33009 | — | — | 1 | 6.38 |
| CHEMBL30774 | — | — | 1 | 6.31 |
| CHEMBL30885 | — | — | 1 | 6.07 |
| CHEMBL30661 | — | — | 1 | 5.96 |
| CHEMBL30240 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2170582 | R-343 | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL1235110 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1190711 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL287478 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2170585 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL431645 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL104279 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL282342 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL104519 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL475251 | R-406 | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL107061 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL30678 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL30548 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL30824 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL30873 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL515271 | R-112 | Ki | = | 96.0 | nM | 7.02 |
| CHEMBL284675 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL318079 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL31141 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL56904 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL30826 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL30355 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL285346 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL285916 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL104813 | — | IC50 | = | 273.0 | nM | 6.56 |
| CHEMBL33009 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL30774 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL30885 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL30661 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL30240 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL31668 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL28 | APIGENIN | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL941 | IMATINIB | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL164 | MYRICETIN | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL105421 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL151 | LUTEOLIN | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL31574 | FISETIN | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL50 | QUERCETIN | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL28626 | MORIN | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL33373 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL33984 | — | IC50 | > | 30.0 | ug.mL-1 | - |
| CHEMBL434202 | — | IC50 | > | 30.0 | ug.mL-1 | - |
| CHEMBL417315 | — | IC50 | > | 30.0 | ug.mL-1 | - |
| CHEMBL30271 | — | IC50 | > | 30.0 | ug.mL-1 | - |