Compound Detail
CHEMBL2170585
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Basic Information
| ChEMBL ID | CHEMBL2170585 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NKTQPBWZINMNES-UHFFFAOYSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
386.4
MW (Da)
4.03
ALogP
7
HBA
2
HBD
89.4
PSA (Ų)
0.47
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 5.97
Ki 1 meas. best 8.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tyrosine-protein kinase SYK CHEMBL2599 | Ki | 8.0 | 8.0 | 10.0 | 1 |
| Tyrosine-protein kinase SYK CHEMBL2599 | EC50 | 5.97 | 5.97 | 1080.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase SYK | Ki | = | 10.0 | nM | 8.0 | Inhibition of SYK | 22257213 |
| Tyrosine-protein kinase SYK | EC50 | = | 1080.0 | nM | 5.97 | Inhibition of SYK assessed as IL4 production by cell based assay | 22257213 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22257213 | 10.1021/jm201271b | Tyrosine-protein kinase SYK | 2 |
Data from ChEMBL 36 via Core Engine