Assay Detail
Binding
CHEMBL2432433
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of kappa opioid receptor (unknown origin) by PDSP assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
N-substituted 8-aminopentacyclo[5.4.0.0(2,6).0(3,10).0(5,9)]undecanes as σ receptor ligands with potential neuroprotective effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 5.88 | 6.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1189234 | — | — | 1 | 6.31 |
| CHEMBL2432039 | — | — | 1 | 6.09 |
| CHEMBL2432059 | — | — | 1 | 6.03 |
| CHEMBL2205827 | — | — | 1 | 5.94 |
| CHEMBL2205829 | — | — | 1 | 5.85 |
| CHEMBL2432057 | — | — | 1 | 5.78 |
| CHEMBL2432051 | — | — | 1 | 5.70 |
| CHEMBL2432045 | — | — | 1 | 5.31 |
| CHEMBL2432050 | — | — | 1 | - |
| CHEMBL2432047 | — | — | 1 | - |
| CHEMBL2205831 | — | — | 1 | - |
| CHEMBL2205830 | — | — | 1 | - |
| CHEMBL2205820 | — | — | 1 | - |
| CHEMBL602850 | — | — | 1 | - |
| CHEMBL2205835 | — | — | 1 | - |
| CHEMBL608560 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1189234 | — | Ki | = | 488.0 | nM | 6.31 |
| CHEMBL2432039 | — | Ki | = | 809.0 | nM | 6.09 |
| CHEMBL2432059 | — | Ki | = | 934.0 | nM | 6.03 |
| CHEMBL2205827 | — | Ki | = | 1147.0 | nM | 5.94 |
| CHEMBL2205829 | — | Ki | = | 1426.0 | nM | 5.85 |
| CHEMBL2432057 | — | Ki | = | 1662.0 | nM | 5.78 |
| CHEMBL2432051 | — | Ki | = | 1977.0 | nM | 5.70 |
| CHEMBL2432045 | — | Ki | = | 4864.0 | nM | 5.31 |
| CHEMBL2432050 | — | Ki | - | — | - | |
| CHEMBL2432047 | — | Ki | - | — | - | |
| CHEMBL2205831 | — | Ki | - | — | - | |
| CHEMBL2205830 | — | Ki | - | — | - | |
| CHEMBL2205820 | — | Ki | - | — | - | |
| CHEMBL602850 | — | Ki | - | — | - | |
| CHEMBL2205835 | — | Ki | - | — | - | |
| CHEMBL608560 | — | Ki | - | — | - |