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Assay Detail

CHEMBL2432453

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of dopamine D3 receptor (unknown origin) by PDSP assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

D(3) dopamine receptor (CHEMBL234)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

N-substituted 8-aminopentacyclo[5.4.0.0(2,6).0(3,10).0(5,9)]undecanes as σ receptor ligands with potential neuroprotective effects.
Banister SD, Manoli M, Barron ML, Werry EL, Kassiou M.
Bioorg Med Chem (2013) 21 : 6038 -6052
PubMed 23981939 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 22 5.38 5.98

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2432051 1 5.98
CHEMBL2429890 1 5.57
CHEMBL1643900 1 5.28
CHEMBL2432039 1 5.27
CHEMBL1643899 1 5.14
CHEMBL2432048 1 5.06
CHEMBL2432038 1 -
CHEMBL2432050 1 -
CHEMBL2432049 1 -
CHEMBL2432047 1 -
CHEMBL2432046 1 -
CHEMBL2205829 1 -
CHEMBL2205830 1 -
CHEMBL2205820 1 -
CHEMBL602850 1 -
CHEMBL2205835 1 -
CHEMBL2205827 1 -
CHEMBL608560 1 -
CHEMBL2432060 1 -
CHEMBL1643902 1 -
CHEMBL2432058 1 -
CHEMBL2205831 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2432051 Ki = 1048.0 nM 5.98
CHEMBL2429890 Ki = 2685.0 nM 5.57
CHEMBL1643900 Ki = 5215.0 nM 5.28
CHEMBL2432039 Ki = 5365.0 nM 5.27
CHEMBL1643899 Ki = 7155.0 nM 5.14
CHEMBL2432048 Ki = 8662.0 nM 5.06
CHEMBL2432038 Ki > 10000.0 nM -
CHEMBL2432050 Ki - -
CHEMBL2432049 Ki - -
CHEMBL2432047 Ki - -
CHEMBL2432046 Ki - -
CHEMBL2205829 Ki - -
CHEMBL2205830 Ki - -
CHEMBL2205820 Ki - -
CHEMBL602850 Ki - -
CHEMBL2205835 Ki - -
CHEMBL2205827 Ki - -
CHEMBL608560 Ki - -
CHEMBL2432060 Ki > 10000.0 nM -
CHEMBL1643902 Ki > 10000.0 nM -
CHEMBL2432058 Ki > 10000.0 nM -
CHEMBL2205831 Ki - -