Assay Detail
Binding
CHEMBL2432454
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Inhibition of dopamine D2 receptor (unknown origin) by PDSP assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
N-substituted 8-aminopentacyclo[5.4.0.0(2,6).0(3,10).0(5,9)]undecanes as σ receptor ligands with potential neuroprotective effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 5.27 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2205831 | — | — | 1 | 5.55 |
| CHEMBL2432058 | — | — | 1 | 5.29 |
| CHEMBL2432039 | — | — | 1 | 5.25 |
| CHEMBL2432049 | — | — | 1 | 5.00 |
| CHEMBL2432050 | — | — | 1 | - |
| CHEMBL2432048 | — | — | 1 | - |
| CHEMBL2432047 | — | — | 1 | - |
| CHEMBL2205830 | — | — | 1 | - |
| CHEMBL2205820 | — | — | 1 | - |
| CHEMBL602850 | — | — | 1 | - |
| CHEMBL2205835 | — | — | 1 | - |
| CHEMBL608560 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2205831 | — | Ki | = | 2830.0 | nM | 5.55 |
| CHEMBL2432058 | — | Ki | = | 5096.0 | nM | 5.29 |
| CHEMBL2432039 | — | Ki | = | 5675.0 | nM | 5.25 |
| CHEMBL2432049 | — | Ki | = | 9906.0 | nM | 5.00 |
| CHEMBL2432050 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2432048 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2432047 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2205830 | — | Ki | - | — | - | |
| CHEMBL2205820 | — | Ki | - | — | - | |
| CHEMBL602850 | — | Ki | - | — | - | |
| CHEMBL2205835 | — | Ki | - | — | - | |
| CHEMBL608560 | — | Ki | - | — | - |