Assay Detail
Functional
CHEMBL2433429
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Cytotoxicity against human HL60 cells assessed as cell viability after 72 hrs by MTT assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Bioactive oleanane-type saponins from the rhizomes of Anemone taipaiensis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.01 | 6.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.51 |
| CHEMBL2430029 | — | — | 1 | 5.62 |
| CHEMBL2430031 | — | — | 1 | 5.21 |
| CHEMBL444982 | — | — | 1 | 5.04 |
| CHEMBL1171448 | CIRENSENOSIDE O | — | 1 | 4.97 |
| CHEMBL447565 | ALPHA-HEDERIN | — | 1 | 4.93 |
| CHEMBL452911 | — | — | 1 | 4.84 |
| CHEMBL168 | OLEANOLIC_ACID | — | 1 | 4.79 |
| CHEMBL2430037 | — | — | 1 | 4.67 |
| CHEMBL495641 | SIARESINOLIC ACID | — | 1 | 4.59 |
| CHEMBL486400 | HEDERAGENIN | — | 1 | 4.56 |
| CHEMBL2430036 | — | — | 1 | 4.41 |
| CHEMBL2430030 | — | — | 1 | - |
| CHEMBL1256616 | NIMUSTINE HYDROCHLORIDE | — | 1 | - |
| CHEMBL2430035 | — | — | 1 | - |
| CHEMBL2430034 | — | — | 1 | - |
| CHEMBL2430033 | — | — | 1 | - |
| CHEMBL2430032 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL2430029 | — | IC50 | = | 2370.0 | nM | 5.62 |
| CHEMBL2430031 | — | IC50 | = | 6130.0 | nM | 5.21 |
| CHEMBL444982 | — | IC50 | = | 9130.0 | nM | 5.04 |
| CHEMBL1171448 | CIRENSENOSIDE O | IC50 | = | 10780.0 | nM | 4.97 |
| CHEMBL447565 | ALPHA-HEDERIN | IC50 | = | 11780.0 | nM | 4.93 |
| CHEMBL452911 | — | IC50 | = | 14520.0 | nM | 4.84 |
| CHEMBL168 | OLEANOLIC_ACID | IC50 | = | 16170.0 | nM | 4.79 |
| CHEMBL2430037 | — | IC50 | = | 21560.0 | nM | 4.67 |
| CHEMBL495641 | SIARESINOLIC ACID | IC50 | = | 25940.0 | nM | 4.59 |
| CHEMBL486400 | HEDERAGENIN | IC50 | = | 27520.0 | nM | 4.56 |
| CHEMBL2430036 | — | IC50 | = | 38640.0 | nM | 4.41 |
| CHEMBL2430030 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL1256616 | NIMUSTINE HYDROCHLORIDE | IC50 | - | — | - | |
| CHEMBL2430035 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL2430034 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL2430033 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL2430032 | — | IC50 | > | 80000.0 | nM | - |