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Compound Detail

CHEMBL1171448

CIRENSENOSIDE O
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C[C@@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](OC[C@H]3O[C@@H](OC(=O)[C@]45CCC(C)(C)C[C@H]4C4=CC[C@@H]6[C@@]7(C)CC[C@H](O)C(C)(C)[C@@H]7CC[C@@]6(C)[C@]4(C)CC5)[C@H](O)[C@@H](O)[C@@H]3O)O[C@@H]2CO)[C@H](O)[C@H](O)[C@H]1O

Basic Information

ChEMBL ID CHEMBL1171448
Name CIRENSENOSIDE O
Phase Preclinical
Structure Type MOL
InChI Key QDUNASUIHMLOJM-VYEWMGKISA-N
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names

Molecular Properties

927.1
MW (Da)
1.17
ALogP
17
HBA
10
HBD
274.8
PSA (Ų)
0.12
QED
3
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C48H78O17
MW 927.13
Aromatic Rings 0
Heavy Atoms 65
NP-Likeness 2.61

Activity Summary

IC50 5 meas. best 4.97

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
HL-60
CHEMBL383
IC50 4.97 4.97 10780.0 1
HepG2
CHEMBL395
IC50 4.92 4.92 12090.0 1
NON-PROTEIN TARGET
CHEMBL3879801
IC50 4.86 4.86 13930.0 1
HeLa
CHEMBL399
IC50 4.65 4.65 22390.0 1
A549
CHEMBL392
IC50 4.58 4.58 26130.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
30808589 10.1016/j.bmcl.2019.02.022 RAW264.7 2
20540535 10.1021/np100057y Prostaglandin G/H synthase 2 1
20540535 10.1021/np100057y Prostaglandin G/H synthase 1 1
23992864 10.1016/j.bmcl.2013.08.006 NON-PROTEIN TARGET 1
23992864 10.1016/j.bmcl.2013.08.006 HeLa 1
23992864 10.1016/j.bmcl.2013.08.006 A549 1
23992864 10.1016/j.bmcl.2013.08.006 HL-60 1
23992864 10.1016/j.bmcl.2013.08.006 HepG2 1

Data from ChEMBL 36 via Core Engine