Assay Detail
Binding
CHEMBL2437506
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Antagonist activity at human glucagon receptor
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Computational neural network analysis of the affinity of 2-pyridyl-3,5-diaryl pyrroles analogs for the human glucagon receptor using density functional theory
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 6.38 | 8.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL88486 | — | — | 1 | 8.28 |
| CHEMBL10 | SB-203580 | — | 1 | 7.43 |
| CHEMBL91652 | — | — | 1 | 7.36 |
| CHEMBL160525 | — | — | 1 | 7.30 |
| CHEMBL158989 | — | — | 1 | 7.30 |
| CHEMBL350255 | — | — | 1 | 7.10 |
| CHEMBL423781 | — | — | 1 | 7.04 |
| CHEMBL17370 | — | — | 1 | 6.93 |
| CHEMBL160314 | — | — | 1 | 6.79 |
| CHEMBL160490 | — | — | 1 | 6.79 |
| CHEMBL348401 | — | — | 1 | 6.74 |
| CHEMBL159163 | — | — | 1 | 6.72 |
| CHEMBL160550 | — | — | 1 | 6.68 |
| CHEMBL160690 | — | — | 1 | 6.58 |
| CHEMBL159198 | — | — | 1 | 6.52 |
| CHEMBL160627 | — | — | 1 | 6.49 |
| CHEMBL157529 | — | — | 1 | 6.47 |
| CHEMBL158477 | — | — | 1 | 6.38 |
| CHEMBL160281 | — | — | 1 | 6.38 |
| CHEMBL160638 | — | — | 1 | 6.38 |
| CHEMBL2435136 | — | — | 1 | 6.17 |
| CHEMBL158671 | — | — | 1 | 6.10 |
| CHEMBL436022 | — | — | 1 | 6.00 |
| CHEMBL155694 | — | — | 1 | 5.94 |
| CHEMBL2435137 | — | — | 1 | 5.91 |
| CHEMBL160238 | — | — | 1 | 5.87 |
| CHEMBL328126 | — | — | 1 | 5.85 |
| CHEMBL351772 | — | — | 1 | 5.84 |
| CHEMBL160289 | — | — | 1 | 5.77 |
| CHEMBL160380 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL88486 | — | IC50 | = | 5.309 | nM | 8.28 |
| CHEMBL10 | SB-203580 | IC50 | = | 37.07 | nM | 7.43 |
| CHEMBL91652 | — | IC50 | = | 44.06 | nM | 7.36 |
| CHEMBL160525 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL158989 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL350255 | — | IC50 | = | 80.17 | nM | 7.10 |
| CHEMBL423781 | — | IC50 | = | 90.16 | nM | 7.04 |
| CHEMBL17370 | — | IC50 | = | 117.22 | nM | 6.93 |
| CHEMBL160490 | — | IC50 | = | 160.32 | nM | 6.79 |
| CHEMBL160314 | — | IC50 | = | 160.32 | nM | 6.79 |
| CHEMBL348401 | — | IC50 | = | 180.3 | nM | 6.74 |
| CHEMBL159163 | — | IC50 | = | 190.11 | nM | 6.72 |
| CHEMBL160550 | — | IC50 | = | 210.38 | nM | 6.68 |
| CHEMBL160690 | — | IC50 | = | 260.02 | nM | 6.58 |
| CHEMBL159198 | — | IC50 | = | 300.61 | nM | 6.52 |
| CHEMBL160627 | — | IC50 | = | 320.63 | nM | 6.49 |
| CHEMBL157529 | — | IC50 | = | 340.41 | nM | 6.47 |
| CHEMBL158477 | — | IC50 | = | 420.73 | nM | 6.38 |
| CHEMBL160638 | — | IC50 | = | 420.73 | nM | 6.38 |
| CHEMBL160281 | — | IC50 | = | 420.73 | nM | 6.38 |
| CHEMBL2435136 | — | IC50 | = | 671.43 | nM | 6.17 |
| CHEMBL158671 | — | IC50 | = | 801.68 | nM | 6.10 |
| CHEMBL436022 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL155694 | — | IC50 | = | 1150.8 | nM | 5.94 |
| CHEMBL2435137 | — | IC50 | = | 1230.27 | nM | 5.91 |
| CHEMBL160238 | — | IC50 | = | 1361.44 | nM | 5.87 |
| CHEMBL328126 | — | IC50 | = | 1402.81 | nM | 5.85 |
| CHEMBL351772 | — | IC50 | = | 1442.12 | nM | 5.84 |
| CHEMBL160289 | — | IC50 | = | 1690.44 | nM | 5.77 |
| CHEMBL160380 | — | IC50 | = | 2654.61 | nM | 5.58 |
| CHEMBL160401 | — | IC50 | = | 2805.43 | nM | 5.55 |
| CHEMBL156458 | — | IC50 | = | 2844.46 | nM | 5.55 |
| CHEMBL347663 | — | IC50 | = | 3767.04 | nM | 5.42 |
| CHEMBL158535 | — | IC50 | = | 4742.42 | nM | 5.32 |
| CHEMBL346698 | — | IC50 | = | 14223.29 | nM | 4.85 |