Compound Detail
CHEMBL423781
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Basic Information
| ChEMBL ID | CHEMBL423781 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IOTPUQIURNWCBL-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
358.4
MW (Da)
5.25
ALogP
2
HBA
2
HBD
66.0
PSA (Ų)
0.52
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.05
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mitogen-activated protein kinase 14 CHEMBL260 | IC50 | 7.05 | 7.05 | 90.0 | 2 |
| Glucagon receptor CHEMBL1985 | IC50 | 7.04 | 7.04 | 90.2 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mitogen-activated protein kinase 14 | IC50 | = | 90.0 | nM | 7.05 | Inhibitory activity against p38-alpha kinase | 10201821 |
| Mitogen-activated protein kinase 14 | IC50 | = | 90.0 | nM | 7.05 | Inhibitory activity against Mitogen-activated protein kinase 14, p38-alpha | 16250656 |
| Glucagon receptor | IC50 | = | 90.16 | nM | 7.04 | Antagonist activity at human glucagon receptor | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10201821 | 10.1016/s0960-894x(99)00081-5 | Glucagon receptor | 4 |
| 10201821 | 10.1016/s0960-894x(99)00081-5 | Mitogen-activated protein kinase 14 | 1 |
| 10201821 | 10.1016/s0960-894x(99)00081-5 | Unchecked | 1 |
| 16250656 | 10.1021/jm050563r | Glucagon receptor | 1 |
| 16250656 | 10.1021/jm050563r | Mitogen-activated protein kinase 14 | 1 |
| - | 10.1007/s00044-013-0801-3 | Glucagon receptor | 1 |
Data from ChEMBL 36 via Core Engine