Assay Detail
ADMET
CHEMBL2439899
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CYP2C9 in human liver microsomes assessed as inhibition of midazolam metabolism by HPLC/MS analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsome |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.86 | 4.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2436981 | — | — | 1 | 4.86 |
| CHEMBL2436976 | — | — | 1 | - |
| CHEMBL2436983 | — | — | 1 | - |
| CHEMBL2436982 | — | — | 1 | - |
| CHEMBL2436980 | — | — | 1 | - |
| CHEMBL2436978 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2436981 | — | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL2436976 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL2436983 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL2436982 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL2436980 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL2436978 | — | IC50 | > | 30000.0 | nM | - |