Assay Detail
Binding
CHEMBL2446504
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human recombinant carbonic anhydrase 6 expressed in Escherichia coli Rosetta2 (DE3) by thermal shift assay
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Benzenesulfonamides with pyrimidine moiety as inhibitors of human carbonic anhydrases I, II, VI, VII, XII, and XIII.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 43 | 5.69 | 7.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.48 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.75 |
| CHEMBL2010995 | — | — | 1 | 6.70 |
| CHEMBL406 | INDAPAMIDE | 4.0 | 1 | 6.60 |
| CHEMBL2010989 | — | — | 1 | 6.54 |
| CHEMBL2010807 | — | — | 1 | 6.30 |
| CHEMBL2011155 | — | — | 1 | 6.25 |
| CHEMBL2010999 | — | — | 1 | 6.17 |
| CHEMBL2010991 | — | — | 1 | 6.08 |
| CHEMBL2010987 | — | — | 1 | 6.05 |
| CHEMBL2011156 | — | — | 1 | 6.04 |
| CHEMBL2010997 | — | — | 1 | 6.00 |
| CHEMBL2011152 | — | — | 1 | 5.96 |
| CHEMBL2010992 | — | — | 1 | 5.90 |
| CHEMBL2010990 | — | — | 1 | 5.89 |
| CHEMBL2443196 | — | — | 1 | 5.72 |
| CHEMBL2443189 | — | — | 1 | 5.72 |
| CHEMBL2010993 | — | — | 1 | 5.70 |
| CHEMBL2443203 | — | — | 1 | 5.68 |
| CHEMBL2010996 | — | — | 1 | 5.60 |
| CHEMBL2443194 | — | — | 1 | 5.60 |
| CHEMBL2443188 | — | — | 1 | 5.60 |
| CHEMBL2010998 | — | — | 1 | 5.60 |
| CHEMBL2443202 | — | — | 1 | 5.55 |
| CHEMBL2443204 | — | — | 1 | 5.54 |
| CHEMBL2443192 | — | — | 1 | 5.48 |
| CHEMBL2443197 | — | — | 1 | 5.48 |
| CHEMBL2443190 | — | — | 1 | 5.48 |
| CHEMBL2010988 | — | — | 1 | 5.43 |
| CHEMBL2443193 | — | — | 1 | 5.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18 | ETHOXZOLAMIDE | Kd | = | 33.0 | nM | 7.48 |
| CHEMBL20 | ACETAZOLAMIDE | Kd | = | 180.0 | nM | 6.75 |
| CHEMBL2010995 | — | Kd | = | 200.0 | nM | 6.70 |
| CHEMBL406 | INDAPAMIDE | Kd | = | 250.0 | nM | 6.60 |
| CHEMBL2010989 | — | Kd | = | 290.0 | nM | 6.54 |
| CHEMBL2010807 | — | Kd | = | 500.0 | nM | 6.30 |
| CHEMBL2011155 | — | Kd | = | 560.0 | nM | 6.25 |
| CHEMBL2010999 | — | Kd | = | 670.0 | nM | 6.17 |
| CHEMBL2010991 | — | Kd | = | 830.0 | nM | 6.08 |
| CHEMBL2010987 | — | Kd | = | 900.0 | nM | 6.05 |
| CHEMBL2011156 | — | Kd | = | 910.0 | nM | 6.04 |
| CHEMBL2010997 | — | Kd | = | 1000.0 | nM | 6.00 |
| CHEMBL2011152 | — | Kd | = | 1100.0 | nM | 5.96 |
| CHEMBL2010992 | — | Kd | = | 1250.0 | nM | 5.90 |
| CHEMBL2010990 | — | Kd | = | 1300.0 | nM | 5.89 |
| CHEMBL2443196 | — | Kd | = | 1900.0 | nM | 5.72 |
| CHEMBL2443189 | — | Kd | = | 1900.0 | nM | 5.72 |
| CHEMBL2010993 | — | Kd | = | 2000.0 | nM | 5.70 |
| CHEMBL2443203 | — | Kd | = | 2100.0 | nM | 5.68 |
| CHEMBL2010998 | — | Kd | = | 2500.0 | nM | 5.60 |
| CHEMBL2443188 | — | Kd | = | 2500.0 | nM | 5.60 |
| CHEMBL2010996 | — | Kd | = | 2500.0 | nM | 5.60 |
| CHEMBL2443194 | — | Kd | = | 2500.0 | nM | 5.60 |
| CHEMBL2443202 | — | Kd | = | 2800.0 | nM | 5.55 |
| CHEMBL2443204 | — | Kd | = | 2900.0 | nM | 5.54 |
| CHEMBL2443192 | — | Kd | = | 3330.0 | nM | 5.48 |
| CHEMBL2443197 | — | Kd | = | 3300.0 | nM | 5.48 |
| CHEMBL2443190 | — | Kd | = | 3300.0 | nM | 5.48 |
| CHEMBL2010988 | — | Kd | = | 3700.0 | nM | 5.43 |
| CHEMBL2443193 | — | Kd | = | 4300.0 | nM | 5.37 |
| CHEMBL2443198 | — | Kd | = | 4500.0 | nM | 5.35 |
| CHEMBL2011154 | — | Kd | = | 5000.0 | nM | 5.30 |
| CHEMBL2011000 | — | Kd | = | 5000.0 | nM | 5.30 |
| CHEMBL2443206 | — | Kd | = | 5000.0 | nM | 5.30 |
| CHEMBL2010994 | — | Kd | = | 5000.0 | nM | 5.30 |
| CHEMBL2443191 | — | Kd | = | 5000.0 | nM | 5.30 |
| CHEMBL2011153 | — | Kd | = | 5000.0 | nM | 5.30 |
| CHEMBL2443195 | — | Kd | = | 7100.0 | nM | 5.15 |
| CHEMBL2443207 | — | Kd | = | 8300.0 | nM | 5.08 |
| CHEMBL2443200 | — | Kd | = | 9100.0 | nM | 5.04 |
| CHEMBL2443205 | — | Kd | = | 13000.0 | nM | 4.89 |
| CHEMBL2443199 | — | Kd | = | 13000.0 | nM | 4.89 |
| CHEMBL2443201 | — | Kd | = | 40000.0 | nM | 4.40 |