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Assay Detail

CHEMBL2446804

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antitrypanosomal activity against trypomastigote form of Trypanosoma cruzi Y assessed as parasite growth inhibition after 24 hrs by Neubauer cell counting method
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma cruzi
Cell Type Neubauer
Confidence 1 — Organism
Curated By Autocuration

Target

Trypanosoma cruzi (CHEMBL368)
Type ORGANISM
Organism Trypanosoma cruzi

Publication

Synthesis and anti-Trypanosoma cruzi activity of naphthoquinone-containing triazoles: electrochemical studies on the effects of the quinoidal moiety.
Diogo EB, Dias GG, Rodrigues BL, Guimarães TT, Valença WO, Camara CA, de Oliveira RN, da Silva MG, Ferreira VF, de Paiva YG, Goulart MO, Menna-Barreto RF, de Castro SL, da Silva Júnior EN.
Bioorg Med Chem (2013) 21 : 6337 -6348
PubMed 24074878 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 27 4.78 5.17

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2441128 1 5.17
CHEMBL2441129 1 5.09
CHEMBL454129 1 4.76
CHEMBL2441127 1 4.09
CHEMBL2441131 1 -
CHEMBL2441130 1 -
CHEMBL2441126 1 -
CHEMBL2441125 1 -
CHEMBL2441124 1 -
CHEMBL2441123 1 -
CHEMBL2441122 1 -
CHEMBL2441121 1 -
CHEMBL2441132 1 -
CHEMBL2441119 1 -
CHEMBL2441118 1 -
CHEMBL2441117 1 -
CHEMBL2441116 1 -
CHEMBL2441115 1 -
CHEMBL2375550 1 -
CHEMBL2375477 1 -
CHEMBL2375478 1 -
CHEMBL2375552 1 -
CHEMBL2375476 1 -
CHEMBL2375474 1 -
CHEMBL2375473 1 -
CHEMBL2441133 1 -
CHEMBL2441120 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2441128 IC50 = 6800.0 nM 5.17
CHEMBL2441129 IC50 = 8200.0 nM 5.09
CHEMBL454129 IC50 = 17300.0 nM 4.76
CHEMBL2441127 IC50 = 80800.0 nM 4.09
CHEMBL2441131 IC50 > 1500000.0 nM -
CHEMBL2441130 IC50 > 4000000.0 nM -
CHEMBL2441126 IC50 > 4000000.0 nM -
CHEMBL2441125 IC50 > 4000000.0 nM -
CHEMBL2441124 IC50 > 4000000.0 nM -
CHEMBL2441123 IC50 > 4000000.0 nM -
CHEMBL2441122 IC50 > 4000000.0 nM -
CHEMBL2441121 IC50 > 4000000.0 nM -
CHEMBL2441132 IC50 > 3200000.0 nM -
CHEMBL2441119 IC50 > 4000000.0 nM -
CHEMBL2441118 IC50 > 4000000.0 nM -
CHEMBL2441117 IC50 > 4000000.0 nM -
CHEMBL2441116 IC50 > 4000000.0 nM -
CHEMBL2441115 IC50 > 4000000.0 nM -
CHEMBL2375550 IC50 > 4000000.0 nM -
CHEMBL2375477 IC50 > 4000000.0 nM -
CHEMBL2375478 IC50 > 2000000.0 nM -
CHEMBL2375552 IC50 > 1500000.0 nM -
CHEMBL2375476 IC50 > 500000.0 nM -
CHEMBL2375474 IC50 > 4000000.0 nM -
CHEMBL2375473 IC50 > 2000000.0 nM -
CHEMBL2441133 IC50 = 318200.0 nM -
CHEMBL2441120 IC50 > 4000000.0 nM -