Assay Detail
Binding
CHEMBL2447158
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Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 60 mins by ELISA
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 2-amino-5-aryl-3-benzylthiopyridine scaffold based potent c-Met inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 7.19 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL601719 | CRIZOTINIB | 4.0 | 1 | 8.96 |
| CHEMBL2442124 | — | — | 1 | 8.11 |
| CHEMBL2442126 | — | — | 1 | 7.79 |
| CHEMBL2442127 | — | — | 1 | 7.67 |
| CHEMBL2442118 | — | — | 1 | 7.66 |
| CHEMBL2442140 | — | — | 1 | 7.59 |
| CHEMBL2442136 | — | — | 1 | 7.58 |
| CHEMBL2442134 | — | — | 1 | 7.42 |
| CHEMBL2442114 | — | — | 1 | 7.35 |
| CHEMBL2442131 | — | — | 1 | 7.35 |
| CHEMBL2442113 | — | — | 1 | 7.34 |
| CHEMBL2442139 | — | — | 1 | 7.30 |
| CHEMBL2442132 | — | — | 1 | 7.23 |
| CHEMBL2442129 | — | — | 1 | 7.21 |
| CHEMBL2442120 | — | — | 1 | 7.19 |
| CHEMBL2442137 | — | — | 1 | 7.18 |
| CHEMBL2442116 | — | — | 1 | 7.12 |
| CHEMBL2442117 | — | — | 1 | 7.09 |
| CHEMBL2442121 | — | — | 1 | 7.01 |
| CHEMBL2442119 | — | — | 1 | 7.00 |
| CHEMBL2071450 | — | — | 1 | 7.00 |
| CHEMBL2442128 | — | — | 1 | 6.99 |
| CHEMBL2442138 | — | — | 1 | 6.88 |
| CHEMBL2442135 | — | — | 1 | 6.82 |
| CHEMBL2442112 | — | — | 1 | 6.77 |
| CHEMBL2442123 | — | — | 1 | 6.76 |
| CHEMBL2442122 | — | — | 1 | 6.71 |
| CHEMBL2442130 | — | — | 1 | 6.64 |
| CHEMBL2442133 | — | — | 1 | 6.64 |
| CHEMBL2442115 | — | — | 1 | 6.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL2442124 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL2442126 | — | IC50 | = | 16.4 | nM | 7.79 |
| CHEMBL2442127 | — | IC50 | = | 21.4 | nM | 7.67 |
| CHEMBL2442118 | — | IC50 | = | 22.1 | nM | 7.66 |
| CHEMBL2442140 | — | IC50 | = | 25.8 | nM | 7.59 |
| CHEMBL2442136 | — | IC50 | = | 26.5 | nM | 7.58 |
| CHEMBL2442134 | — | IC50 | = | 38.1 | nM | 7.42 |
| CHEMBL2442114 | — | IC50 | = | 44.9 | nM | 7.35 |
| CHEMBL2442131 | — | IC50 | = | 44.9 | nM | 7.35 |
| CHEMBL2442113 | — | IC50 | = | 45.3 | nM | 7.34 |
| CHEMBL2442139 | — | IC50 | = | 50.5 | nM | 7.30 |
| CHEMBL2442132 | — | IC50 | = | 58.7 | nM | 7.23 |
| CHEMBL2442129 | — | IC50 | = | 61.8 | nM | 7.21 |
| CHEMBL2442120 | — | IC50 | = | 64.9 | nM | 7.19 |
| CHEMBL2442137 | — | IC50 | = | 66.2 | nM | 7.18 |
| CHEMBL2442116 | — | IC50 | = | 76.8 | nM | 7.12 |
| CHEMBL2442117 | — | IC50 | = | 81.7 | nM | 7.09 |
| CHEMBL2442121 | — | IC50 | = | 97.9 | nM | 7.01 |
| CHEMBL2442119 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL2071450 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL2442128 | — | IC50 | = | 101.7 | nM | 6.99 |
| CHEMBL2442138 | — | IC50 | = | 130.2 | nM | 6.88 |
| CHEMBL2442135 | — | IC50 | = | 151.8 | nM | 6.82 |
| CHEMBL2442112 | — | IC50 | = | 171.4 | nM | 6.77 |
| CHEMBL2442123 | — | IC50 | = | 173.2 | nM | 6.76 |
| CHEMBL2442122 | — | IC50 | = | 196.4 | nM | 6.71 |
| CHEMBL2442130 | — | IC50 | = | 228.7 | nM | 6.64 |
| CHEMBL2442133 | — | IC50 | = | 228.3 | nM | 6.64 |
| CHEMBL2442115 | — | IC50 | = | 240.3 | nM | 6.62 |
| CHEMBL2071448 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL2071449 | — | IC50 | = | 320.0 | nM | 6.50 |