Compound Detail
CHEMBL2071448
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Basic Information
| ChEMBL ID | CHEMBL2071448 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SJNLAUPYSAFIFO-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
408.3
MW (Da)
4.00
ALogP
5
HBA
2
HBD
85.8
PSA (Ų)
0.64
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.55
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Hepatocyte growth factor receptor CHEMBL3717 | IC50 | 6.55 | 6.55 | 280.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Hepatocyte growth factor receptor | IC50 | = | 280.0 | nM | 6.55 | Inhibition of c-Met incubated for 60 mins at spectrophotometry | 22863529 |
| Hepatocyte growth factor receptor | IC50 | = | 280.0 | nM | 6.55 | Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate afte... | 23993328 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22863529 | 10.1016/j.bmc.2012.07.007 | Hepatocyte growth factor receptor | 1 |
| 22863529 | 10.1016/j.bmc.2012.07.007 | NON-PROTEIN TARGET | 1 |
| 23993328 | 10.1016/j.bmc.2013.07.032 | Hepatocyte growth factor receptor | 1 |
Data from ChEMBL 36 via Core Engine